ObjectiveTo determine whether vaginal progesterone for programmed endometrial preparation is noninferior to intramuscular in terms of live birth rates from frozen embryo transfer (FET).DesignThree-armed, randomized, controlled noninferiority trial.SettingMulticenter fertility clinic.Patient(s)A total 1,346 volunteer subjects planning vitrified-warmed high-quality nonbiopsied blastocysts were sc...

Objective: A generic vaginal progesterone gel has recently been developed in China. Little is known about its pharmacokinetic properties in Chinese subjects. The purpose of our study was to investigate the pharmacokinetics of three forms of vaginal progesterone gel (test formulations at 4 and 8% strength vs. a reference formulation: Crinone 8%) in Chinese healthy post-menopausal women. Methods:...

Preterm deliveries is the major contributors of neonatal mortalities and under 5 age group morbidities. Excessive use Progesterone its supplements, antenatal steroidal cover tocolysis prevents this. In this study, there has been made an attempt to study perinatal outcome both mother neonate revolving around premature by using two different routes for progesterone administration. A prospective w...

Background: Women with preterm labor put in an arrest phase by tocolytic therapy, are at increased risk of recurrent preterm labor. The aim of this study is to evaluate vaginal progesterone suppositories as compared to intramuscular type in order to prevent preterm labor in women with episodes of threatened preterm labor. Methods: This prospective longitudinal...

OBJECTIVE Alpha Lipoic Acid (ALA) is a safe natural molecule that exerts a selective immunomodulating activity with antioxidant and anti-inflammatory properties. This randomized controlled clinical trial (RCT) tested the effect of the vaginal administration with ALA or Progesterone, in subchorionic hematoma resorption in women with threatened miscarriage. PATIENTS AND METHODS 400 mg of vagina...

Preterm birth is a major health problem for the neonate, family, country, and society in general. Despite many risk factors being identified for women destined to deliver preterm, short cervical length detected on transvaginal ultrasound is the most plausible, practical and sensitive risk factor for prediction of spontaneous preterm birth. The definition of short cervix has varied in various st...

The objective of this study was to determine the effect of medroxyprogesterone acetate (DMPA) on the development and maintenance of Candida albicans in the vagina of oophorectomized Wistar rats. The animals were divided into negative control groups (NCG), which received injections of sterile saline; positive control groups (PCG), which were given injections of estradiol valerate; and progestero...

BACKGROUND In IVF, Luteal phase support is usually performed using vaginal progesterone. A part of patients using this route reports being uncomfortable with this route. We tried to study whether the rectal route could be an effective alternative and associated with less discomfort. PATIENTS AND METHODS A prospective randomized controlled study. All patient were eligible for IVF treatment for...

OBJECTIVE The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. STUDY DESIGN A randomized, double-blind, placebo-controlled study included 142 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administered daily by vaginal suppository and all patients underwent uterine contracti...