Although GABA neurotransmission has been suggested as a mechanism for Valeriana officinalis effects, CNS depression can also be evoked by inhibition of ionotropic (iGluR) and metabotropic glutamate receptors (mGluR). In this study, we examined if aqueous valerian extract interacted with glutamatergic receptors. Freshly prepared aqueous valerian extract was incubated with rat cortical synaptic m...

Plant remedies, despite their innocuity reputation, are implicated in adverse events. The present review focuses on 30 popular herbs which are associated with severe and sometimes fatal hepatotoxicity: Actaea racemosa, Aloe barbadensis, Atractylis gummifera, Callilepsis laureola, Camellia sinensis, Centella asiatica, Chelidonium majus, Ephedra sinica, Garcinia cambogia, Hypericum perforatum, La...