BACKGROUND AND THE PURPOSE OF THE STUDY Domperidone (DOM) is a dopamine- receptor (D(2)) antagonist, which is widely used in the treatment of motion-sickness. The pharmacokinetic parameters make DOM a suitable candidate for transdermal delivery. The purpose of the present investigation was to develop transdermal delivery systems for DOM and to evaluate their physicochemical characteristics, in ...

it was difficult to obtain directly in a single experiment films of exactly 0.1-mm. thickness, several films were selected so that the thickness of each film might be distributed in a range from 0.05 to 0.4 mm. and the respective water vapor permeability was measured at various humidity conditions. Plotting the relationship between permeation resistance (l/Q) and film thickness (I) gave a strai...

in the present work, b-zsm-5 zeolite membranes were synthesized on porous tubular α-alumina supports by several subsequence in situ crystallization hydrothermal treatments. the tio2- bohmite and ɣ- alumina intermediate layers were applied to improve the lattice matching between zeolite layer and the support. the uniform membrane intermediate layers with low permeation resistance were prepared o...

It is the purpose of this chapter to provide standards for the functional properties of packaging systems used for solid oral dosage forms (SODF) and liquid oral dosage forms (LODF) for pharmaceuticals and dietary supplements. Definitions that apply to this chapter are provided in Packaging and Storage Requirements á659ñ. The tests that follow are provided to determine the moisture vapor transm...

The well-known fluorophore, namely 1,3,6,8-tetrakis[(trimethylsilyl)ethynyl]pyrene, has been studied profoundly as a fluorescent sensor toward nitroaromatic compounds in solutions and vapor phase. Three prototypes of materials for sensing were prepared via electrospinning drop-casting onto the melamine formaldehyde foam with fluorophore pure solid or dopant polystyrene matrix. It shown that thi...

The deposition of yttria-doped zirconia has been experimented systematically in various types of porous ceramic substrates by a modified chemical vapor deposition (CVD) process operating in an opposing reactant geometry using water vapor and corresponding metal chloride vapors as reactants. The effects of substrate pore dimension and structure, bulk-phase reactant concentration, reactant diffus...

A multilayer composite ceramic membrane was prepared by depositing a nano-scale layer of SiO2 on top of a modified porous alumina support by chemical vapor deposition (CVD) method. The modification of the support was carried out by adding a graded layer of Al2O3 (γ-alumina phase), using sol-gel method. An optimized temperature of 700 K for intermediate layer calcination was gained by XRD analys...

This study aims to investigate the applicability of vacuum membrane distillation for concentrating aqueous lithium bromide solution, and to analyze the feasibility of applying vacuum membrane distillation process to the absorption refrigeration system. Hydrophobic polyvinylidene fluoride (PVDF) was adopted as the membrane material, and was made into hollow fiber membrane module. Commercial aque...