Neurons in cold-blooded animals remarkably maintain their function over a wide range of temperatures, even though the rates of many cellular processes increase twofold, threefold, or many-fold for each 10°C increase in temperature. Moreover, the kinetics of ion channels, maximal conductances, and Ca(2+) buffering each have independent temperature sensitivities, suggesting that the balance of bi...

Whether nasal obstruction disturbs sleep and nocturnal breathing is controversial because convenient techniques for measuring nasal resistance during sleep are lacking. Therefore, we developed a technique for unobtrusive, side-selective nasal conductance monitoring. The technique measures left and right nasal airflow and transnasal pressure using nasal cannulas, thin catheters inserted through ...

Large-conductance Ca(2+)- and voltage-activated K(+) (BK) channels have the largest conductance (250-300 pS) of all K(+)-selective channels. Yet, the contributions of the various parts of the ion conduction pathway to the conductance are not known. Here, we examine the contribution of the entrance to the inner cavity to the large conductance. Residues at E321/E324 on each of the four α subunits...

,4BSTRACT TASAKI, I. AND C. S. SPYROPOULOS. Membrane conductance and currentvoltage relation in the squid axon under ‘voltage-clamp.’ &L-The conductance of the squid axon membrane under ‘voltage-clamp’ was measured by superposing a sinusoidal wave upon rectangular clamping voltage pulses. It was possible to determine the time course of the emf of the membrane under ‘voltage-clamp’ on a single p...

The highly variable dynamics of neocortical circuits observed in vivo have been hypothesized to represent a signature of ongoing stochastic inference but stand in apparent contrast to the deterministic response of neurons measured in vitro. Based on a propagation of the membrane autocorrelation across spike bursts, we provide an analytical derivation of the neural activation function that holds...

We report an analysis of low-temperature measurements of the conductance of partially disordered reduced graphene oxide, finding that the data follow a simple crossover scenario. At room temperature, the conductance is dominated by two-dimensional (2D) electric field-assisted, thermally driven (Pollak-Riess) variable-range hopping (VRH) through highly disordered regions. However, at lower tempe...

Very little is known about the autonomic psychophysiological responses while individuals are executing a Symptom Validity Test. Therefore, the aim of this study is to analyze the peripheral psychophysiological correlates (electrodermal conductance and heart rate) during the performance of the Victoria Symptom Validity Test (VSVT). The sample of this study was composed of 30 participants who und...

Hot flashes are experienced by over 70% of menopausal women. Criteria to classify hot flashes from physiologic signals show variable performance. The primary aim was to compare conventional criteria to Support Vector Machines (SVMs), an advanced machine learning method, to classify hot flashes from sternal skin conductance. Thirty women with > or =4 hot flashes/day underwent laboratory hot flas...

20 Throughout the nervous system, cells belonging to a certain electrical class (e-class) sharing high similarity in 21 firing response properties may nevertheless have widely variable dendritic morphologies. To quantify the 22 effect of this morphological variability on the firing of layer 5 thick-tufted pyramidal cells (TTCs), a detailed 23 conductance-based model (CBM) was constructed for a ...