The possible interrelation between male reproductive disorders and iris pigmentation is poorly understood. We have found a link between eye colour and the existence of adolescent varicocele. Therefore, we aimed to extend our investigation on the relationship between the eye colour and varicocele in adult men. 231 andrology outpatients from Caucasian origin were included in the study. The presen...

PURPOSE Because varicocele is seen often in infertile men and oxidative stress has been implicated in sperm dysfunction, we assessed spermatozoal reactive oxygen species and seminal total antioxidant capacity in men with and without varicocele. MATERIALS AND METHODS Levels of reactive oxygen species and total antioxidant capacity were measured in the semen of 21 infertile men with varicocele,...

Varicocele is the most common diagnosis in men presenting to fertility clinics, Table 1.1 The incidence of varicocele in the general population has been reported to be 13.4% or greater, whereas 37% or more of infertile men have been noted to have varicoceles.2 The World Health Organization (WHO) investigated the influence of varicocele on fertility in men presenting to infertility clinics and c...

OBJECTIVES Varicocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients. MATERIALS AND METHODS We determined the POLG CAG repeat len...

OBJECTIVE To investigate: 1) the impact of clinical varicocele on reactive oxygen species (ROS) levels in neat and washed semen in a proven fertile population; and 2) the correlation between ROS levels, testicular volume, and varicocele grade in the same population of fertile men. DESIGN Prospective controlled clinical study. SETTING Andrology laboratory at tertiary-care hospital. PATIENT...

Background: To compare the c l in ica l e f fec t o f varicocelectomy treatment between patients who were diagnosed as secondary varicocele caused by nutcracker syndrome (NCS) and primary varicocele patients. Methods: The secondary varicocele patients combined with NCS admitted in our hospital were systematically reviewed. All these patients had no obvious related symptoms such as gross hematur...

OBJECTIVE To evaluate varicocele effects on conventional semen parameters: sperm DNA fragmentation, chromatin packaging, mitochondrial membrane potential (MMP) and sperm apoptosis. METHODS A cross-sectional study was carried out with semen samples from 2,399 men of couples who attended an infertility clinic. A total of 16.3% (391/2399) of the men were diagnosed with varicocele by a urologist....

Varicocele is characterized by abnormal tortuosity and dilation of the veins of the pampiniform plexus within the spermatic cord. Although several reports show the mechanisms by which the varicocele exerts its infertility impact, the exact pathophysiology for varicocele-induced inflammation and its relationship with testicular endocrine disruption remain largely unknown. This review article wil...

PURPOSE To elucidate the impact of surgical varicocele repair on the pregnancy rate through new meta-analyses of randomized clinical trials that compared surgical varicocele repair and observation. MATERIALS AND METHODS The PubMed and Embase online databases were searched for studies released before December 2012. References were manually reviewed, and two researchers independently extracted ...

BACKGROUND Prepubertal varicocele has the most devastating effects on the testes. Oxidative stress is the major cause leading to infertility in varicocele. The antioxidant properties of Flaxseed (FS) treatment in some oxidative diseases have been reported. OBJECTIVE This study aimed to evaluate the antioxidant effect of FS in prepubertal rats with experimental varicocele. MATERIALS AND METH...