Erectile dysfunction following radical prostatectomy remains a frequent problem despite the development of nerve-sparing techniques. This erectile dysfunction is believed to be neurogenic, enhanced by hypoxia-induced structural changes which result in additional veno-occlusive dysfunction. Recently, daily use of intracavernous vasoactive substances and oral use of PDE5-inhibitors have been clin...

Abstract. Iontophoresis currents are used in the transcutaneous delivery of vasoactive substances for noninvasive assessment of skin vascular properties. The blood flow rate can be recorded by laser Doppler flowmetry (LDF), its average value and the amplitudes of its oscillatory components being used to evaluate the effect of the drugs. Because non-drug-specific, current-induced, vasodilation c...

Objective(s): The main objective of this study was to investigate the variations of β-endorphin (β-EP), vasoactive intestinal peptide (VIP), serotonin (5-HT) and norepinephrine (NE) of immune thrombocytopenia (ITP) mice as well as the regulatory mechanism of prednison. Materials and Methods: Sixty BALB/c mice were randomly divided into control group, model group and prednison intervention grou...

The renin–angiotensin system is important for the regulation of vascular smooth muscle tone, fluid and electrolyte balance, and the growth of cardiac and vascular smooth muscle. A normally functioning renin– angiotensin system contributes to the routine control of arterial blood pressure. A variety of basic and clinical investigations have resulted in a broader understanding of the role of the ...

• H. Croxatto et al. have demonstrated that on incubation for 24 hours at 38 C. and pll 3.8 to 4, the serum of each of the animals they studied (including mammals, birds, and amphibia) produced a peptide which causes smooth muscle contraction. This peptitle: lias been named "auephrotonsin.'' Slight pharmacological differences were found among the anephrotensins obtained from the. several types ...

Objective(s) The aim of this study was to investigate the overall effect of cardiac vasoactive factors during coronary occlusion and reperfusion on peripheral vascular tone, using a sequential isolated rabbit heart-ear perfusion model. Materials and Methods Isolated ears were perfused with the effluent of isolated hearts subjected to ischemia (30 min) and reperfusion (180 min, n=6). The comp...

Cirrhosis is a pathological entity characterized by the association of hepatocyte necrosis, fibrosis and regenerative nodules; hemodynamic and neurohormonal metabolic factors intervening in its development mechanisms, resulting in hepatic stellate cell activation and transformation and development of liver fibrosis. Cytokines are key modulators of liver cell fibroblast transformation. Prostagla...

Clifford, Philip S., and Ylva Hellsten. Vasodilatory mechanisms in contracting skeletal muscle. J Appl Physiol 97: 393–403, 2004; 10.1152/japplphysiol.00179. 2004.—Skeletal muscle blood flow is closely coupled to metabolic demand, and its regulation is believed to be mainly the result of the interplay of neural vasoconstrictor activity and locally derived vasoactive substances. Muscle blood flo...

To assess the effects of dietary vasoactive amines in the aetiology of childhood migraine, 39 children were randomly allocated to either a high fibre diet low in these substances or a high fibre diet alone. Both groups of children showed a significant decrease in the number of headaches and there was no significant difference between the two groups. Dietary vasoactive amines have not been shown...