Ca(2+)/calmodulin- and voltage-dependent inactivation (CDI and VDI) comprise vital prototypes of Ca(2+) channel modulation, rich with biological consequences. Although the events initiating CDI and VDI are known, their downstream mechanisms have eluded consensus. Competing proposals include hinged-lid occlusion of channels, selectivity filter collapse, and allosteric inhibition of the activatio...

Introduction Angiogenesis, the formation and development of new vascular network, is essential to tumor growth. Vascular network surrounding tumor tissues, however, exhibits abnormal functional and structural properties distinct from normal blood vessel. Functional abnormalities include higher permeability and altered blood flow, etc. Tumor vascular permeability can be assessed in vivo by using...

BACKGROUND Smoking, excessive drinking, and physical inactivity are associated with reduced cognitive function but the independence, domain specific cognitive effects, and trajectories of these associations are not firmly established. OBJECTIVE Our aim was to examine these lifestyle-cognitive function associations in middle-to-older aged women across time. METHODS Cohort study design with r...

M it der Richtlinie VDI 3766 [1] wurde nun der zweite Entwurf einer Richtlinie fertiggestellt, die die Durchführung entsprechender Messungen an Arbeitsplätzen und deren Beurteilung sowie geeignete Lärmminderungsmaßnahmen beschreibt. Da die Meinungen bezüglich der Beurteilung von Ultraschallgeräuschen und der dabei anzusetzenden Grenzwerte stark divergierten, hat die Erarbeitung dieser Richtlini...

This paper presents an analysis of the FI4VDI project, the goal of which was to develop an innovative model of service provision using cloud computing in order to create an infrastructure suite aimed at large companies and SMEs alike, educational institutions, universities and/or research centers that would contribute to competitiveness and provide an efficient solution to reducing the carbon f...

BACKGROUND Phospholemman (PLM) is an important phosphorylation substrate for protein kinases A and C in the heart. Until now, the association between PLM phosphorylation status and L-type calcium channels (LTCCs) gating has not been fully understood. We investigated the kinetics of LTCCs in HEK 293T cells expressing phosphomimetic or nonphosphorylatable PLM mutants. METHODS The LTCCs gating w...

BACKGROUND In acute liver failure (ALF) therapeutic plasma exchange (TPE) improves laboratory measures of liver function. In patients with ALF requiring minimal vasoactive support TPE has also been shown to provide haemodynamic benefits including an increase in systemic blood pressure. However the haemodynamic effects of TPE in patients with severe ALF requiring moderate or high dose vasopresso...

OBJECTIVE To determine survival, organ damage and predictors of these outcomes in a population-based, longitudinal cohort study of patients with Wegener's granulomatosis (WG). METHODS In a retrospective study, 56 WG patients (median age 50 yr) were followed for 56.5 months. Clinical and laboratory data, disease activity, organ involvement and the Vasculitis Damage Index (VDI) were recorded at...