The horizontal saccade, smooth pursuit, and vestibulo-ocular reflex gains were recorded in 19 patients with cerebellar infarction documented with MRI, and in a group of control subjects. Bilateral saccade hypometria and a decrease in ipsilateral smooth pursuit gain were found only in patients with a lesion affecting the posterior vermis. These results in humans support experimental findings sug...

We describe two infants in whom rhombencephalosynapsis was diagnosed with MR imaging in vivo. In contrast to Dandy-Walker malformation, the vermian maldevelopment in this anomaly is characterized by an absence of the anterior vermis and a deficiency of the posterior vermis. The cerebellar hemispheres are fused. In an attempt to identify the pathogenesis of these anatomic manifestations, we ques...

Joubert syndrome (JS) and Meckel syndrome (MKS) are pleiotropic ciliopathies characterized by severe defects of the cerebellar vermis, ranging from hypoplasia to aplasia. Interestingly, ciliary conditional mutant mice have a hypoplastic cerebellum in which the proliferation of cerebellar granule cell progenitors (GCPs) in response to Sonic hedgehog (SHH) is severely reduced. This suggests that ...

MR imaging depicted vertically oriented folia instead of the normal horizontal folial pattern, hypoplastic cerebellar vermis, fusion of the inferior posterior cerebellum, and probable polymicrogyria in the superior cerebellar hemispheres in a child with hypotonia, nystagmus, ataxia, and psychomotor retardation. We propose that this newly discovered cerebellar malformation be added to the list o...

OBJECTIVE The authors previously reported that men with chronic schizophrenia had a smaller vermian subregion than did healthy men. In this study, they tested whether posterior superior vermis reduction would be seen in a larger group of schizophrenia patients, both male and female. METHOD Brain volumetric analyses were performed with magnetic resonance imaging (MRI) in 59 male and female pat...

In the last decade a growing body of data revealed that the cerebellum is involved in the regulation of the affective reactions as well as in forming the association between sensory stimuli and their emotional values. In humans, cerebellar areas around the vermis are activated during mental recall of emotional personal episodes and during learning of a CS-US association. Lesions of the cerebell...

OBJECTIVE To describe the sonographic appearance and temporal changes of the structures of the posterior cranial fossa in fetuses at a crown-rump length (CRL) between 45 and 84 mm in transvaginal acquired three-dimensional volume blocks. METHODS This was a prospective, cross-sectional, observational study including 80 fetuses, whose mothers attended Kepler University Hospital Linz or the Ambu...

BACKGROUND AND PURPOSE We report abnormal high T2 signal intensity in the anterior lobe of the cerebellar vermis that we believe was the result of profound hypoxic ischemic encephalopathy in the perinatal period in term infants. We tested the hypothesis that this sign was associated with other signs of significant perinatal hypoxic damage. METHODS Thirty patients with clinically and radiologi...

OBJECTIVES We aimed to compare concentrations of N-acetyl aspartate, myo-inositol, and other neurometabolites in the cerebellar vermis of offspring at risk for bipolar disorder (BD) and healthy controls to examine whether changes in these neuronal metabolite concentrations occur in at-risk offspring prior to the onset of mania. METHODS A total of 22 children and adolescents aged 9-17 years wi...