vesicoureteral reflux (vur) is one of the most important causes of urinary tract infection and renal failure in children. it is a potentially self-limited disease. the aim of this study was to evaluate the clinical course and significant factors in children with primary vur. the medical charts of 125 infants and children (27.2 % males, 72.8% females) with all grades of primary vur were retrospe...

OBJECTIVE Screening siblings of index patients with vesicoureteral reflux (VUR) has been proposed to identify children who are at risk for renal damage. However, screening siblings for VUR remains controversial. We investigated the prevalence of VUR and renal cortical abnormalities in the sibling population in a large cohort of families with VUR. METHODS Between 1998 and 2012, parents of inde...

Reflux nephropathy, or renal parenchymal scarring associated with vesicoureteral reflux (VUR), is an important cause of renal failure. Some studies have shown that in up to 10% of adults and 30% of children requiring renal replacement therapy for end-stage renal disease, reflux nephropathy is the cause of the renal failure. Reflux nephropathy is thought to result from the combination of VUR of ...

196 cases with vesicoureteral reflux (VUR) from multiple centers were analysed to examine the relationship between VUR and reflux nephropathy. The high correlation (p less than 0.01) was observed between reflux and renal scarring. Even in cases in whom VUR was not demonstrated at the time of testing, renal scarring of various degrees was recognized, suggesting either co-existed hypoplastic kidn...

Renal failure has a complex phenotype resulting from an underlying kidney disease as well as environmental and genetic factors. In the present study we performed a systematic review and meta-analyses to evaluate the association of the A1166C polymorphism of Angiotensin II type 1 Receptor gene (AGTR1) with Chronic Kidney Disease (CKD), End Stage Renal Disease (ESRD), IgA Nephropathy (IgAN) and V...

* Corresponding author Seyed Taher Esfahani, MD Department of Pediatric Nephrology Children Medical Center Dr. Gharib St., Azadi Ave. Tehran, IRAN Tel: +9821-66929234 Fax: +9821-66930024 E-mail: esfahanisedtaher@ yahoo.com Introduction: The association of sacral anomalies with fecal incontinence and lower urinary tract dysfunction is known. The sacral ratio is proposed as a tool for evaluation ...

In the mid-1980’s, the Aarhus group headed by the two pioneers in Nocturnal Enuresis research Jens-Christian Djurhuus and Jens Peter Nørgaard, reported the first data correlating the degree of Vesicoureteral Reflux (VUR) and associated nephropathy to the presence of enuresis (1). The material showed that one half of the patients with reflux also had enuresis, and that in spite of identical demo...

Solitary crossed renal ectopia (SCRE) represents an exceedingly rare congenital disorder. Although skeletal and genitourinary abnormalities most commonly accompany this condition, vesicoureteral reflux (VUR) has been described in only a few cases. Here, we present two unique cases of SCRE complicated by high-grade VUR concomitant with posterior urethral valve in one case and hypospadias in the ...

Vesicoureteral reflux is uncommonly diagnosed and treated after puberty. The natural history of uncorrected VUR after puberty is not documented. Postpubertal patients with recurrent pyelonephritis and VUR should be considered for treatment. Ureteral reimplantation, endoscopic injections, and laparoscopic or robotic ureteral reimplantation may be utilized. Endoscopic injection is an appealing op...

This study was conducted to investigate whether the length of the interval between a urinary tract infection and the performance of the voiding cystourethrogram influences the presence or severity of vesicoureteral reflux (VUR). In this study 161 children with first episode of urinary tract infection were evaluated. Depending on time of performance of voiding cystourethrogram (VCUG), patients d...