The study aimed to investigate extracts of un-ripe pods Vinca rosea cv. Pink for antidiabetic activity and polyphenol-based characterization using HPLC. Moreover, the molecular interaction identified markers with targets was explored molecular-docking software. Different were prepared investigated models such as glucose uptake by yeast cells, alpha amylase inhibition haemoglobin-glycosylation a...

The experimental activity of a new clinically confirmed anti tumor compound, Vincaleukoblastine (C46HssOgN4), (VLB) as the sulfate has been described. Greatest activity was seen against the P-1534 acute lymphocytic leukemia in DBA/~ mice. Late as well as early stages of this leukemia were significantly affected by this compound. No synergistic or additive effects have been observed in combinati...

Vincaleukoblastine (VLB) is a compound recently isolated from Vinca rosea L i n n . Chemical studies by Gorman et al. (6) indicated that it belongs to a new class of dimeric alkaloids containing both indole and dihydroindole moieties. VLB possesses a marked leukopenic effect, due to depression of leukopoiesis (4, 10). I t has been found that this alkaloid is active against several animal tumors...

Dehydrodiconiferyl alcohol glucosides (DCGs) are derivatives of the phenylpropanoid pathway that have been isolated from Catharansus roseus L. (Vinca rosea) crown gall tumors. Fractions containing purified DCGs have been shown previously to promote the growth of cytokinin-requiring tissues of tobacco in the absence of exogenous cytokinins. In this study, we utilized synthetic DCG isomers to con...

In 1995, Canadian scientists Robert Noble and Charles Beer were inducted into the Canadian Medical Hall of Fame for their 1950s "discovery" of Vinblastine. Their "chance" finding of an anticancer drug in the leaves of the periwinkle plant (Vinca rosea, Linn.), is used to explore the historical issue of discovery, accidental discovery, and priority. The elements of the discovery are reconstructe...

Vincaleukoblastine (VLB) is a compound recently isolated from Vinca rosea L i n n . Chemical studies by Gorman et al. (6) indicated that it belongs to a new class of dimeric alkaloids containing both indole and dihydroindole moieties. VLB possesses a marked leukopenic effect, due to depression of leukopoiesis (4, 10). I t has been found that this alkaloid is active against several animal tumors...