There are few cohort studies describing the adaptive functioning profile for Pitt-Hopkins syndrome (PTHS). In this study we examine PTHS and compare it to Angelman (AS). Caregivers of 14 individuals with PTHS, 33 deletion AS 23 non-deletion AS, completed Vineland Adaptive Behavior Scales-II. The in was characterised by strengths socialisation, followed motor skills, communication then daily liv...

This study explored whether young children with Down syndrome show praxis deficits that impact activities of daily living, and whether these deficits are specific to Down syndrome. We compared the performance of young children with Down syndrome, a mental age-matched group of children with developmental disabilities of mixed or unknown etiologies, and a group of typically developing infants and...

BACKGROUND: The purpose of the current study was to evaluate the relationships among sleep problems and daytime behaviors in a large, well-defined cohort of children with autism spectrum disorder (ASD). METHODS: Out of a registry population of 3452 children with ASDs, a subset of 1193 children aged 4 to 10 years of age from 14 centers across the country was used to evaluate the relationship bet...

Adaptive behavior rating scales are frequently used to gather information on the adaptive functioning of children with high-functioning autism spectrum disorders (HFASDs), yet little is known about the extent to which these measures yield comparable results. This study was conducted to (a) document the parent-rated VABS-II, BASC-2, and ABAS-II adaptive behavior profiles of 6- to 11-year-olds wi...

Main outcome measures Assessment of symptoms of autism (Autism Behaviour Checklist and Treatment/Side Effect Behaviour Scale by parents and ADOS-G by clinicians), language (Preschool Language Scale III [PLS-3]) and ADOS-G), visual spatial attention task, and physiological and/or gastrointestinal (GI) symptoms (parent questionnaires). Cognitive function (Leiter International Performance Scale-Re...

Treatments targeting metabolic abnormalities in children with autism are limited. Previously we reported that a nutritional treatment significantly improved glutathione metabolism in children with autistic disorder. In this study we evaluated changes in adaptive behaviors in this cohort and determined whether such changes are related to changes in glutathione metabolism. Thirty-seven children d...

Vineland Adaptive Behavior Scales (VABS) data were examined in a large sample of young children with ASD (n = 290) of varying cognitive levels. IQ was higher than VABS composite score among high functioning children only; the opposite pattern was found in lower IQ subgroups. Profile analysis of VABS domains across cognitive levels demonstrated different profiles in different subgroups. A charac...

This study compared parent-reported sleep characteristics in 2- to 5-year-old children with autism spectrum disorders (ASD) to children with other developmental delays (DD) and typical development (TD). We included 529 children (303 ASD [167 males], 63 DD [46 males], and 163 TD [134 males]) enrolled in the CHARGE study, an ongoing population-based case-control study. The mean age of participant...

The Active Vibration and Noise Reduction (AVINOR) aeroelastic simulation code for helicopter rotor blades is described. AVINOR is a research code that has been developed at UCLA and the University of Michigan for the purpose of conducting computationally efficient aeroelastic response analyses while maintaining a level of fidelity so as to be suitable for preliminary design of helicopter rotor ...

OBJECTIVES To study cognitive test profiles with a focus on processing speed in a representative group of preschool children with autism spectrum disorder (ASD) and relate processing speed to adaptive functioning. METHODS Cognitive assessments were performed in 190 3.6-6.6-year-old children (164 boys and 26 girls) with ASD, using either Griffiths' developmental scales (n = 77) or the Wechsler...