Copper is a cofactor for numerous coenzymes and metalloproteins essential for normal neurologic function. Th e most common neurological presentations of copper defi ciency are myelopathy, polyneuropathy and optic neuropathy. Here we present two cases of sensorimotor polyneuropathy, copper defi ciency and microcytic anemia in conjunction with allopurinol management for gout. Th ese two patients ...

Folic acid is an essential water soluble B vitamin which has been used for decades in the prevention of folate defi ciency anemia of pregnancy. In 1991, folic acid taken prior to the start of pregnancy was shown unequivocally to prevent spina bifi da and anencephaly—two of the most serious and common birth (neural tube) defects. Soon governments recommended that women of reproductive age consum...

Introduction . Over the past decade, incidence of iron deficiency anemia has increased. According to World Health Organization (WHO), it occurs in every 3 people world. Most often, developing countries and is mainly affected by 2 groups population — young children pregnant women. In pediatric practice, there are single works devoted problem comorbidity, connection with which our studies particu...

During the 16th and 17th centuries maize, a New World cereal defi cient in niacin (vitamin B3 or PP), replaced cereals of higher economic and nutritional value in the staple diet of the poor in Southern Europe. As a consequence of quasi-monophagic maize porridge-based diets pellagra, a lethal new disease due to severe niacin defi ciency, spread dramatically among the Southern European peasantry...

Choline is a water-soluble nutrient that is often grouped with the vitamin B complex. However, its functions suggest it is more than just another vitamin. Choline is crucial for the normal function of all cells (Zeisel and Blusztajn, 1994). It is needed for the structural integrity and signaling functions of cell membranes; it directly affects cholinergic neurotransmission; it is the major sour...

The synt hetic retinoids represent a new class of drugs wh ich a re highly effective in t he treatment of a broad spectrum of dermatologic d isease, including cystic acne, psori asis, and cutaneous di sorders of keratinization [1 3]. Moreover, t he use of synthetic retinoids in cancer prevent ion and therapy fo r both cutaneous and in te rna l t umors is potent ially the most signi ficant clini...

Pompe disease is an autosomal recessive disorder characterized by acid alpha-glucosidase (GAA) defi ciency that results in intralysosomal glycogen accumulation affecting skeletal muscles with more specifi c impairment of proximal limb, trunk, and respiratory muscles. Pulmonary symptoms may represent one of the initial manifestations of late-onset Pompe disease (LOPD) in patients, even those sti...

Background Given that all human organs have vitamin D receptors, it is not surprising that vitamin D3 de ciency can also cause disease symptoms in the lungs. Known diseases include productive and obstructive bronchitis, asthma, chronic obstructive pulmonary disease (COPD), and frequent respiratory infections [1, 2]. To date, there is insu cient data to support whether vitamin D replacement impr...