نتایج جستجو برای: vitamin e succinate
تعداد نتایج: 1105440 فیلتر نتایج به سال:
challenge for efficient treatment. Therefore, a search for novel agents active against this type of cancer is warranted. We tested two vitamin E (VE) analogs, the esterase-hydrolyzable a-tocopheryl succinate (a-TOS) and the non-hydrolyzable ether a-tocopheryloxyacetic acid (a-TEA) for their effects on HER2-positive breast carcinomas using a breast tumor mouse model and breast cancer cell lines....
In the present study we have established that the antitumor activity of alpha-tocopheryl succinate (TS, vitamin E succinate) and cholesteryl succinate (CS) result from the action of the intact TS and CS compounds and not from the release of alpha-tocopherol, cholesterol, or succinate. We report that treatment of murine leukemia cell lines C1498 (myeloid) and L1210 (lymphocytic), with the tris s...
School of Medical Science, Griffith University, Southport 4222, Qld, Australia, Department of Chemistry, University of Otago, Dunedin 9016, New Zealand, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Nathan 4111, Qld, Australia, Institute of Biotechnology, Academy of Sciences of the Czech Republic, Prague 14220, Czech Republic, Department of Chemistry and Physics, Loui...
BACKGROUND Free radical formation and oxidative stress might play an important role in the pathogenesis of Parkinson's disease (PD). In vitro data indicate that neuromelanin (NM) pigment is formed the excess cytosolic catecholamine that is not accumulated into synaptic vesicles via the vesicular monoamine transporter 2 (VMAT2). We designed this study to investigate the neuroprotective effects o...
Alpha-tocopheryl succinate (alpha-TOS), a redox-inactive analogue of vitamin E, is a strong inducer of apoptosis, whereas alpha-tocopherol (alpha-TOH) lacks apoptogenic activity (J. Neuzil et al., FASEB J., 15: 403-415, 2001). Here we investigated the possible antineoplastic activities of alpha-TOH and alpha-TOS and further explored the potential of alpha-TOS as an antitumor agent. Using nude m...
Human glutathione S-transferase omega 1-1 (hGSTO1-1) is a newly identified member of the glutathione S-transferase (GST) family of genes, which also contains alpha, mu, pi, sigma, theta, and zeta members. hGSTO1-1 catalyzes the reduction of arsenate, monomethylarsenate (MMA(V)), and dimethylarsenate (DMA(V)) and exhibits thioltransferase and dehydroascorbate reductase activities. Recent evidenc...
vitamin e (alpha-tocopherol) is a potent and natural antioxidant. vitamin e is concentrated from soybean oil. the committee on fetus and newborn of the academy of the american of pediatrics endorsed 1 to 2 mg/dl as the normal range of serum tocopherol level. human infants are born with low stores of vitamin e, thus they require an adequate intake of vitamin e soon after birth. the optimum intra...
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