vitex agnus-castus l. is a medicinal plant which is used in several dosage forms for women hormonal disorders and standardized according to the iridoids or flavonoids content. aucubin, an iridoid glycoside, considered as a marker in some formulations. in this research, a thin layer chromatographic method with densitometric detection has been developed for quantitative determination of aucubin i...

introduction: lower level of estrogen hormone is considered as an important factor for loss of learning and memory in postmenopausal women. although estrogen replacement therapy is used for compensation, but long-term usage of estrogen is associated with a higher risk of hormonedependent cancers. phytoestrogens, due to fewer side effects, have been proposed to prevent menopause-related cognitiv...

objective: vitex agnus-castus (vac) and its essential oil have been traditionally used to treat many conditions and symptoms such as premenstrual problems, mastalgia, inflammation, sexual dysfunction, and pain. in this study, the effects of essential oil extracted from vitex agnus-castus (eovac) leaves were investigated in three behavioral models of nociception in adult male wistar rats. materi...

Cyclic mastalgia of varying intensity occurs every month in at least 70% women, persistent pain the mammary glands moderate and severe degree is occur about 50% patients with benign mastopathy. The cause mastodynia morphofunctional rearrangement glandular stromal components tissues expansion ducts proliferation epithelial structures due to a lack progesterone an increase prolactin levels. Thera...

Retinal pathologic angiogenesis is the leading cause of blindness in human generate from age-relatedmacular degeneration (AMD), diabetic retinopathy and premature (ROP).The aim this studyis to investigate effect vitex agnus castus leave extract on induced retinal rabbitsby intravitreal injection VEGF. Alcoholic prepared formulated forintravitreal injection. Twenty four pigmented rabbits include...

Seven new labdane-type diterpenoids, vitextrifolins A-G (1-7), along with eight previously reported analogues, were isolated from the fruits of Vitex trifolia. The structures of 1-7 were elucidated by spectroscopic data interpretation. The isolates were evaluated for their cytotoxicity against four human cancer cell lines (A549, HCT116, HL-60, and ZR-75-30), but all were inactive (IC(50) < 5 μg...

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