5-HT7 receptors have been implicated in the control of locomotion. Here we use 5-HT7 receptor knockout mice to rigorously test whether 5-HT acts at the 5-HT7 receptor to control locomotor-like activity in the neonatal mouse spinal cord in vitro and voluntary locomotion in adult mice. We found that 5-HT applied onto in vitro spinal cords of 5-HT7+/+ mice produced locomotor-like activity that was...

Disynaptic Ia reciprocal inhibition acts, at the spinal level, by actively inhibiting antagonist motor neurons and reducing the inhibition of agonist motor neurons. The deactivation of this pathway in Parkinson's disease is still debated. Disynaptic reciprocal inhibition of H reflexes in the forearm flexor muscles was examined in 15 control subjects and 16 treated parkinsonian patients at rest ...

Patients with Huntington's disease (HD) and relatives at risk were examined with respect to their capacity to produce rapid voluntary motor activity. For this purpose, the fastest possible self-paced single isometric forefinger extensions and the fastest alternating forefinger movements were tested. In addition to these fastest voluntary performances, the time course of spontaneous hyperkinetic...

Sensorimotor adaptation restores and maintains the accuracy of goal-directed movements. It remains unclear whether these adaptive mechanisms modify actions by controlling peripheral premotor stages that send commands to the effectors and/or earlier processing stages involved in registration of target location. Here, we studied the effect of adaptation of saccadic eye movements, a well-establish...

In this article we give a characterization of monoids for which torsion freeness, ((principal) weak, strong) flatness, equalizer flatness or Condition (E) of finitely generated and (mono) cyclic acts and Condition (P) of finitely generated and cyclic acts implies regularity. A characterization of monoids for which all (finitely generated, (mono) cyclic acts are regular will be given too. We als...

Loke Kwok Hien, MBBS Mal, MPM Mal Lecturer Department of Psychological Medicine Faculty of Medicine, University of Malaya Kuala Lumpur, 22-11, Malaysia No accurate statistical data on the incidence of sexual deviation is available mainly because few patients seek treatment voluntarily. When a case is reported in the press, it attracts the attention of the public. Offenders are seldom apprehende...

We propose an alternative market design to the current credit ratings industrial organization. An issuer delegates a pass-through non-monitoring trust to acquire ratings from credit ratings agencies (CRAs). The trust pays outcome contingent fees, such that truth-telling is incentive compatible for CRAs, eliminating ratings inflation. Moreover, because the trust acts as an intermediary, it elimi...

A dozen people who cannot speak and have very limited voluntary muscle control because of cerebral palsy or traumatic brain injury have tried using a new technology called the Camera Mouse to access the computer. Nine of the people were successful, in many cases being able to spell words or run commercial software or access the internet for the first time. The Camera Mouse is non-invasive and u...

Cyberloafing is the voluntary acts of individuals using their companies’ Internet access for nonwork related purposes during working hours. This study examines the impact of personality traits on cyberloafing as measured objectively by time spent by individuals on non-work related purposes. Specifically, we investigated (1) the main effects of Big-Five personality traits (Agreeableness, Conscie...