Folic acid supplementation may meliorate cardiovascular disease risk by improving vascular endothelial structure and function. However, the underlying mechanisms are still lack of a global understanding. To be used, folic acid must be converted to 7,8-dihydrofolate by dihydrofolate reductase to generate one-carbon derivatives serving as important cellular cofactors in the synthesis of nucleotid...

The proteome of zygotic embryos of Acer platanoides L. was analyzed via high-resolution 2D-SDS-PAGE and MS/MS in order to: (1) identify significant physiological processes associated with embryo development; and (2) identify changes in the proteome of the embryo associated with the acquisition of seed dormancy. Seventeen spots were identified as associated with morphogenesis at 10 to 13 weeks a...

Hoffman and Schwartz [13] developed the Lattice Polyhedron model and proved that it is totally dual integral (TDI), and so has integral optimal solutions. The model generalizes many important combinatorial optimization problems such as polymatroid intersection, cut covering polyhedra, min cost aborescences, etc., but has lacked a combinatorial algorithm. The problem can be seen as the blocking ...

The 2010 Deepwater Horizon oil spill resulted in the accidental release of millions barrels of crude oil into the Gulf of Mexico. Photoinduced toxicity following coexposure to ultraviolet (UV) radiation is one mechanism by which polycyclic aromatic hydrocarbons (PAHs) from oil spills may exert toxicity. Mahi-mahi (Coryphaena hippurus), an important fishery resource, have positively buoyant, tra...

“Climate Alarm”, a position of Wroclaw public authorities, is an official recognition issues linked to global climate changes highlighting the urban transport development on sustainable agenda. Anarchists Federation (WAF) has entered debate over further trajectory city by proposing fare-free policy (FFPT) as instrument supporting new path presented with Alarm.” As FFPT being implemented for var...

In a previous study of 20 patients with Merkel cell carcinoma (MCC) we reported that p53 appeared to be positive in specimens from patients with a poor clinical outcome (2). The antibody we used to detect p53 protein, clone PAb1801 (Oncogene Science, Cambridge, Mass.), does not distinguish between mutant and wild-type epitopes of p53. We assumed that, since wild-type p53 is thought to be transi...

Web Application Firewalls (WAFs) are used to detect and block attacks against vulnerable web applications. They distinguish benign requests from rogue requests using a set of filter rules. We present a new timing side channel attack that an attacker can use to remotely distinguish passed requests from requests that the WAF blocked. The attack works also for transparent WAFs that do not leave an...

αβ and γδ lineage T cells are thought to arise from a common CD4(-)CD8(-) progenitor in the thymus. However, the molecular pathways controlling fate selection and maturation of these two lineages remain poorly understood. We demonstrated recently that a ubiquitously expressed ribosomal protein, Rpl22, is selectively required for the development of αβ lineage T cells. Germline ablation of Rpl22 ...

Risks posed by oil spills to coral reefs are difficult to evaluate, partially due to the absence of studies that adequately assess toxicity to relevant coral reef species. Here we experimentally tested the acute toxicity of condensate, representing a fraction of light crude oil, to coral (Acropora tenuis) and sponge (Rhopaloeides odorabile) larvae. The metamorphosis of coral larvae was inhibite...

In a high-resolution small-scale seismic experiment we investigated the shallow structure of the Wadi Araba fault (WAF), the principal fault strand of the Dead Sea Transform System between the Gulf of Aqaba/Eilat and the Dead Sea. The experiment consisted of 8 sub-parallel 1 km long seismic lines crossing the WAF. The recording station spacing was 5 m and the source point distance was 20 m. The...