BACKGROUND Diet-induced weight reduction promotes a decrease in resting energy expenditure that could partly explain the difficulty in maintaining reduced body mass. Whether this reduction remains after stabilized weight loss is still controversial, and the molecular mechanisms are unknown. OBJECTIVE The objective was to investigate the effect of a stabilized 10% weight loss on body compositi...

OBJECTIVE To examine the effect of dairy calcium consumption on weight loss and improvement in cardiovascular disease (CVD) and diabetes indicators among overweight diabetic patients. RESEARCH DESIGN AND METHODS This was an ancillary study of a 6-month randomized clinical trial assessing the effect of three isocaloric diets in type 2 diabetic patients: 1) mixed glycemic index carbohydrate die...

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Preventing weight regain after the loss of excess weight is challenging for people, especially for ethnic minorities in the United States. A 6-month weight loss maintenance intervention designed for Pacific Islanders, called the PILI Lifestyle Program (PLP), was compared with a 6-month standard behavioral weight loss maintenance program (SBP) in a pilot randomized controlled trial using a commu...

Weight regain after weight loss is the most significant impediment to long-term weight reduction. We have developed a rodent paradigm that models the process of regain after weight loss, and we have employed both prospective and cross-sectional analyses to characterize the compensatory adaptations to weight reduction that may contribute to the propensity to regain lost weight. Obese rats were f...

Twenty-five patients sustained an average weight loss of 21.7 pounds on a diet in which 73 per cent of total calories consisted of animal fat. Their "new" weight was maintained on this highfat diet and subsequently on a low-fat diet. Standard Sf 0-12 lipoproteins were highly influenced by dietary fat intake independent of weight change. In contrast the Sf 20-400 fraction was lowered by negative...

Twenty-five patients sustained an average weight loss of 21.7 pounds on a diet in which 73 per cent of total calories consisted of animal fat. Their "new" weight was maintained on this highfat diet and subsequently on a low-fat diet. Standard Sf 0-12 lipoproteins were highly influenced by dietary fat intake independent of weight change. In contrast the Sf 20-400 fraction was lowered by negative...

The independent effects of weight loss and dietary fat modification on serum lipids were investigated in two groups of healthy moderately obese men and women. In one group (sequential group, n = 19), a weight-stable low-fat, low-saturated-fat diet (Low-Sat) was given for 7 weeks (= dietary modification), followed by a 4.2 MJ/day deficit Low-Sat diet for 13 weeks (i.e., weight loss alone). Anoth...

BACKGROUND Weight loss reduces blood pressure, and the Dietary Approaches to Stop Hypertension (DASH) diet has also been shown to lower blood pressure. OBJECTIVE Our goal was to assess the effect on blood pressure of 2 weight-reduction diets: a low-fat diet (LF diet) and a moderate-sodium, high-potassium, high-calcium, low-fat DASH diet (WELL diet). DESIGN After baseline measurements, 63 me...

Obesity is associated with an increased risk of heart failure. Little is known about the impact of dietary changes on the cardiac sequelae in obese patients. Twenty-one obese subjects underwent a 12-week low calorie fasting phase of a formula diet. Transthoracic two-dimensional speckle-tracking echocardiography was performed to obtain systolic left ventricular strain before and after weight los...