Coronary heart disease secondary to atherosclerosis is still the leading cause of death in the US. Animal models used for elucidating the pathogenesis of this disease primarily involve rabbits and pigs. Previous studies from this laboratory have demonstrated intraperitoneal injections of poloxamer 407 (P-407) in both male and female mice will lead to hyperlipidemia and atherosclerosis, suggesti...

the present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (pa) that can be used for the preparation of immediate release pellets formulation. two commercially available grades poloxamer 188 (p 188) and poloxamer 407 (p 407) were selected, and solid dispersions (sds) conta...

Metformin pharmacokinetics are highly dependent upon organic cationic transporters. There is evidence of a change in its renal clearance in hyperlipidemic obese patients, and no information on its metabolic fate. To study some of these aspects, the influence of poloxamer 407 (P407)-induced hyperlipidemia on metformin pharmacokinetics was assessed. Control and P407-treated adult male rats were a...

PAGE I. Precipitating antisera built up in pigeons . . . . . . . . . . . . . . . . . . . . . . . . . Object. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Technique of production . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . thod . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Choice of m...

the hypoglycemic effect of the ethanolic extract of Momordica charantia (cucurbitaceae) was investigated in both normal and streptozotocin - induced diabetic mice. The ethanolic extract of Unriped fruits of M. charantia (800mg/kg) reduced the blood glucose of normal mice from 172 ±3 to 136 ± 5 mg/100ml 4 hours after intrapertitoneal administration (P<0.001), and also significantly lowered the b...

We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%) whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to ...

deadline: April 15, 2001 For information, please contact Ms. Rachelle Anderson: tel 780 407-6576; fax 780407-6672; [email protected]

Islet and pancreas transplantation may compete for a limited number of organs. We analyzed records from the national Swiss transplant registry during a 4-year period to investigate the proportion of donors that are suitable for islet and pancreas transplantation. Suitability for pancreas transplantation was mainly defined as: age 10-45 years; weight <or= 80 kg; BMI <or= 25 kg/m(2); amylasemia <...

agnosed children and adults, respectively, were: 13 and 15 times greater for acute respiratory infection; 6 and 9 times greater for otitis media; 6 and 8 times greater for asthma; 6 and 12 times greater for upper respiratory infection; 5 and 8 times greater for conjunctivitis; 5 times greater (both children and adults) for chronic obstructive pulmonary disease/allied conditions; 5 and 8 times g...