A newly developed mini-scale high shear granulator was used for scale-up study of wet granulation process from 0.2 to 200 L scales. Under various operation conditions and granulation bowl sizes, powder mixture composed of anhydrous caffeine, D-mannitol, dibasic calcium phosphate, pregelatinized starch and corn starch was granulated by adding water. The granules were tabletted, and disintegratio...

Dry granulation via roller compaction is increasingly being used as method for the production of oral solid dosage forms. Advantages include a simplified process compared to wet and inherently continuous nature process. A common problem dry granulation, however, loss compactibility granules ungranulated powders. Here we show novel approach minimize during granulation. The intra-granular additio...

This paper investigates foam granulation in a twin screw extruder as a new continuous wet granulation technique for pharmaceutical powder drug formulations. Foamed aqueous binder has a reportedly lower soak-to-spread ratio than drop or spray liquid addition in batch granulation. This work demonstrates a twin screw extruder configuration for foam granulation and subsequently compares the new app...

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This paper discusses our preliminary trials examining the particle size and particle shape of granules produced by different screw elements in a co-rotating twin-screw extruder. In general, conveying elements did not provide the necessary consolidation to allow large particles to grow in significant quantity, whereas the different mixing elements led to the large particles desired for tablettin...

Purpose: As in-line process analytics are becoming more widely accepted, it is important to illustrate that a measurement of interest will provide the expected outcome if that control point has reached a desired level. This methodology is especially true for novel applications. The purpose of this work was to investigate the role of densification during high shear granulation and the resulting ...