نتایج جستجو برای: wilms tumor gene
تعداد نتایج: 1471282 فیلتر نتایج به سال:
Chromosomes and histology were successfully studied in 33 childhood renal tumors. Thirty-one tumors were classified as one of four subtypes of Wilms' tumor. Of 24 typical Wilms' tumors, 12 had hyperdiploidy with nonrandom trisomies, mostly including +6 and/or +12. Three typical Wilms' tumors with an 11p13 deletion or a pericentric inversion with a break in 11p13 were not associated with aniridi...
Wilms tumor is a primarily sporadic disease, with only 1–2 % of affected individuals having a relative with Wilms tumor. However, bilateral Wilms tumors occur in approximately 5 % of cases, and Wilms tumor has been reported in association with more than 50 different genetic disorders, pointing to an underlying predisposition in further individuals. There is conclusive evidence of an increased r...
Most Wilms' tumors are of low stage, favorable histology, and have a high likelihood of cure with current multimodal therapy. Despite this, there remains a group of patients whose tumors recur for whom intensive salvage regimens result in survival of only 50%. Fitting a Cox proportional hazards model to microarray-based comparative genomic hybridization (aCGH) data on 68 Wilms' tumor samples, w...
Wilms' tumor is a type of kidney cancer that affects young children. Although a number of Wilms' tumor samples have been collected through international trials, the mechanisms underlying its progression remain challenging to determine. Extensive studies have identified somatic mutations at several loci in Wilms' tumorigenesis, including WT1, catenin, Wilms' tumor gene on the X chromosome (WTX) ...
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