OBJECTIVE In the prefrontal cortex, the enzyme catechol O-methyltransferase (COMT) is critical in the metabolic degradation of dopamine, a neurotransmitter hypothesized to influence human cognitive function. The COMT gene contains a functional polymorphism, Val158Met, that exerts a fourfold effect on enzyme activity. The current study investigated whether prefrontal cognition varies with COMT g...

This study explores the relationship of intelligence and age to scores on the Wisconsin Card Sorting Test, a measure of executive function. A sample of 26 normal children with Wechsler Intelligence Scale for Children-III (WISC-III) Full-Scale IQS above 130 and 24 normal children with WISC-III Full-Scale IQS between 110 and 129 were administered the test. A comparison to published norms revealed...

Research has demonstrated impairments in executive functions in Bipolar Mood Disorder patients. Evidence shows that this impairment is present in both periods of active symptoms of the disorder, as well as euthymic stages, and is compounded by mood episodes, especially manic phases. The purpose of this study was to compare the executive performance of a sample of Brazilian bipolar patients in d...

objectives: the aim of this research is to compare cognitive flexibility and adjustment between two groups of students with developmental coordination disorder (dcd) and typically developing students. methods: for this purpose, 50 students with dcd and 50 typically developing students were chosen among 12 primary schools. the developmental coordination disorder questionnaire (dcd-q), adjustment...