background : the rapid  development of  the mining and industry activities increased and many toxic metals  in the environment of the earth's crust has been dissipated  and t  has taken  risks to human exposure, inhalation. today evidence of many  diseases associated with environmental  factors  harmful to repellent bio systems is increasing gradually , the majority of these factors  were man-m...

abstract objective: the previous studies indicated that the tlrs especially toll-like receptor 4) tlr4 (are involved in the process of diabetes. the aim of the present research was to investigate the time course expression pattern of tlr4-a main component of innate immune system- in mrna levels in the heart tissue of diabetic male wistar rats. materials and methods: in this research, adult wist...

The high rate of glycolysis in cancerous tissues, first described by Con in vivo (6) and by Warburg in vitro (@2),suggests that a considerable part of the energy supply for the neoplastic process is derived from the “anaerobic―phase of carbo hydrate catabolism. The low glycogen content characterizing a number of tumors (8—11, 13, I 7) may also indicate that the substrate for this process ...

The prevalence of type 2 diabetes mellitus (T2DM) and hypertension has markedly increased worldwide. The purpose of the present study was to examine the effects of a high-salt intake on the systolic blood pressure (SBP) and vascular responses in WBN/Kob-Leprfa/fa (WBKDF) rats, a new spontaneous animal model of T2DM. Male WBKDF rats and age-matched Wistar rats at 6 weeks of age were each divided...

A Estimulação Elétrica tem mostrado ter efeitos benéficos no processo de cicatrização feridas pele em ratos Wistar. É importante avaliar os da eletroestimulação na reparação a fim garantir otimização sua prática. Objetivo: Este artigo revisão consiste resposta cicatricial Wistar, tratados com microcorrente. Material e método: Realizou-se uma busca nas bases dados eletrônicas PubMed período entr...

Laboratory animals, including rats, play an important role in biomedical research and advances. The human care and management of these animals is an ongoing concern. Since, Trichosomoides infections in rat colonies can interfere with research protocols it is important to know rate of infection and pathology of the infection in the animals used in experimental studies. 275 rats were eviscerated ...

It has been described that histone acetylation levels are decreased in several cellular and in vivo neurodegeneration models as well as in normal brain aging, although the impact of the aging process on histone deacetylases (HDAC) activity yet remains poorly understood. Therefore, our aim was to evaluate the effect of the aging process on HDAC activity in hippocampi and frontal cortices from 3 ...

In our studies with spontaneously hypertensive (SHR), Wistar-Kyoto (WKY), and Wistar rats, we observed normotensive WKY rats with cardiac hypertrophy determined by a greater left ventricular (LV) mass (LVM)-to-body weight (BW) ratio (LVM/BW) than that of normotensive Wistar rats. Thus we compared the following parameters in SHR, WKY, and Wistar rats: LVM/BW, cell capacitance as index of total s...

BACKGROUND Hypertension has been associated to diabetes, and participates in the development of diabetic complications. The spontaneously hypertensive rat (SHR) is the gold standard model for the study of hypertension, and experimental diabetes has been currently investigated in SHR. Wistar-Kyoto rat is usually taken as control for SHR, however, regarding the glycemic homeostasis, WKY may be si...