نتایج جستجو برای: xl gene
تعداد نتایج: 1146384 فیلتر نتایج به سال:
سابقه و هدف: سینوزیت مزمن یکی از بیماریهای شایع بوده و سالانه حدود 30 میلیون نفر در امریکا به این بیماری مبتلا میشوند؛ به نحوی که هزینه درمان آن به حدود 60 میلیون دلار در سال میرسد. هدف از این مطالعه، مقایسه اثر کلاریترومایسین XL و کوآموکسیکلاو بر درمان سینوزیت مزمن باکتریال است. مواد و روشها: در این کارآزمایی بالینی، 59 بیمار با متوسط سن 28 سال که مبتلا به سینوزیت مزمن ثابت شده (از نظر با...
DNAzymes are a novel class of gene suppressors that selectively bind to an RNA substrate by Watson-Crick base pairing and cleave phosphodiester bonds. To explore the potential for therapeutic use of catalytic DNA molecules, active DNAzymes targeting the bcl-xL gene were generated through a multiplex in vitro selection. The DNAzyme-mediated down-regulation of the bcl-xL expression was demonstrat...
Most examples of cell death in animals are controlled by a genetic program that is activated within the dying cell. The apoptotic process is further regulated by a set of genes that act as repressors of cell death. Of these, bcl-2 is expressed in a variety of embryonic and postnatal tissues which suggests a critical role for bcl-2 in organogenesis and tissue homeostasis. Surprisingly, mutant mi...
Factor Xi deficiency has previously been observed mainly in Jews. For 34 of 36 probands with factor XI deficiency in Israel, reliable information on ethnic background was obtained. Of 34 probands 33 were of definite Ashkenazi Jewish origin; 1 was of probable Ashkenazi origin. From a survey of factor Xi levels among 428 unrelated healthy Ashkenazi Jews, 35 had partial factor XI deficiency (facto...
Psychological or physical stress induces an elevation of corticosteroids in the circulating system. We report here that corticosterone (CT) protects cardiomyocytes from apoptotic cell death induced by doxorubicin (Dox), an antineoplastic drug known to induce cardiomyopathy possibly through reactive oxygen species production. The cytoprotection induced by CT is within the range of physiologicall...
OBJECTIVE To analyze both differentially expressed genes and the Bcl-xL protein expression after acute and chronic treatment with fluoxetine in rat C6 glioma cells. METHODS C6 glioma cells were cultured for 24 h or 72 h after treatment with 10 µM fluoxetine, and gene expression patterns were observed using microarray and qRT-PCR. Then, cells were cultured for 6 h, 24 h, 72 h or 96 h after tre...
سابقه و هدف: سینوزیت مزمن یکی از بیماری های شایع بوده و سالانه حدود 30 میلیون نفر در امریکا به این بیماری مبتلا می شوند؛ به نحوی که هزینه درمان آن به حدود 60 میلیون دلار در سال می رسد. هدف از این مطالعه، مقایسه اثر کلاریترومایسین xl و کوآموکسی کلاو بر درمان سینوزیت مزمن باکتریال است. مواد و روش ها: در این کارآزمایی بالینی، 59 بیمار با متوسط سن 28 سال که مبتلا به سینوزیت مزمن ثابت شده (از نظر با...
The gene encoding human IAP-like protein (hILP) is one of several mammalian genes with sequence homology to the baculovirus inhibitor-of-apoptosis protein (iap) genes. Here we show that hILP can block apoptosis induced by a variety of extracellular stimuli, including UV light, chemotoxic drugs, and activation of the tumor necrosis factor and Fas receptors. hILP also protected against cell death...
Purpose BRAF mutation occurs in 8-15% of colon cancers (CC), and is associated with poor prognosis in metastatic disease. Compared to wild-type BRAF (BRAFWT) disease, stage II/III CC patients with BRAF mutant (BRAFMT) tumors have shorter overall survival after relapse; however, time-to-relapse is not significantly different. The aim of this investigation was to identify, and validate, novel pre...
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