نتایج جستجو برای: xlf
تعداد نتایج: 235 فیلتر نتایج به سال:
We assess contribution to the X-ray (above 2 keV) luminosity of the Milky Way from different classes of low-mass binary systems and single stars. We begin by using the RXTE Slew Survey of the sky at |b| > 10 to construct an X-ray luminosity function (XLF) of nearby X-ray sources in the range 10 erg s < Lx < 10 34 erg s (where Lx is the luminosity over 2–10 keV), occupied by coronally active bin...
In mice, along with the assessment of eosinophils, lung function measurements, most commonly carried out by plethysmography, are essential to monitor the course of allergic airway inflammation, to examine therapy efficacy and to correlate animal with patient data. To date, plethysmography techniques either use intubation and/or restraining of the mice and are thus invasive, or are limited in th...
The repair of DNA double-strand breaks by nonhomologous end-joining (NHEJ) is essential for maintenance of genomic integrity and cell viability. Central to the molecular mechanism of NHEJ is DNA ligase IV/XRCC4/XLF complex, which rejoins the DNA. During adenovirus (Ad5) infection, ligase IV is targeted for degradation in a process that requires expression of the viral E1B 55k and E4 34k protein...
Inositol hexakisphosphate (InsP(6)) is a member of the inositol polyphosphate group that participates in numerous intracellular signaling pathways. Cheung and colleagues previously reported that InsP(6) stimulated double-strand break repair by nonhomologous end joining (NHEJ) in cell-free extracts and that InsP(6) binding by the Ku70/80 subunit of the DNA-dependent protein kinase (DNA-PK) was r...
We present a comparison of the SZ cluster counts predicted by the Press-Schechter (PS) mass function (MF) and the X-ray luminosity function (XLF) of clusters. The employment of the cluster XLF, together with the observationally determined X-ray luminosity(LX)-temperature(T ) relation, may allow us to estimate the SZ cluster counts in a more realistic manner, although such an empirical approach ...
Repair of DNA double-strand breaks (DSBs) by the nonhomologous end-joining pathway (NHEJ) is important not only for repair of spontaneous breaks but also for breaks induced in developing lymphocytes during V(D)J (variable [V], diversity [D], and joining [J] genes) recombination of their antigen receptor loci to create a diverse repertoire. Mutations in the NHEJ factor XLF result in extreme sens...
In this study, a new crossover sine model (CSM) n was developed from a trigonometric model [M. E. Fisher, S. Zinn, and P. J. Upton, Phys. Rev. B 59, 14533 (1999)]. The trigonometric model is a parametric formulation model that is used to represent the thermodynamic variables near a critical point. Although there are other crossover models based on this trigonometric model, such as the CSM and t...
In this work, we present detailed constraints on the metallicity dependence of high-mass X-ray binary (HMXB) luminosity function (XLF). We analyze ?5 Ms Chandra data for 55 actively star-forming galaxies at D ? 30 Mpc, with gas-phase metallicities spanning ? 7–9.2. Within galactic footprints, our sample contains a total 1311 point sources, which ?49% are expected to be HMXBs, remaining sources ...
Classical nonhomologous end joining (C-NHEJ) is a major mammalian DNA double-strand break (DSB) repair pathway that is required for assembly of antigen receptor variable region gene segments by V(D)J recombination. Recombination activating gene endonuclease initiates V(D)J recombination by generating DSBs between two V(D)J coding gene segments and flanking recombination signal sequences (RS), w...
By analyzing the Chandra ACIS S3 data we studied the X-ray properties of the low-mass and high-mass X-ray binary populations in the nearby spiral galaxy NGC 5055. A total of 43 X-ray point sources were detected within the 2 effective radii, with 31 sources located on the disk and the rest 12 sources in the bulge. The resolved point sources dominate the total X-ray emission of the galaxy by acco...
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