An altered expression of the Yc subunit gene of rat glutathione S-transferase (GST) in the liver of the LEC rat, which is a mutant strain with spontaneous hereditary hepatitis associated with severe jaundice, has been reported. To provide further information concerning the structure of the Yc subunit gene, we carried out the Southern blot hybridization analysis of DNA samples from rats of eight...

Nitric oxide (NO) is known to affect synaptic plasticity in various regions of the brain via the cGMP-cGMP-dependent protein kinase (PKG) pathway. We found that a novel compound 3-(5-hydroxymethyl-2-furyl)-1-benzyl-indazole (YC-1), a drug known to modulate the response of soluble guanylyl cyclase to NO, greatly potentiates long-term potentiation (LTP). This compound markedly enhanced the induct...

Multiparous (n = 26) and primiparous (n = 18) Holstein cows were fed prepartum and postpartum total mixed diets that were, or were not, supplemented with a yeast culture (YC) for approximately 23 d prepartum and 56 d postpartum. Multiparous cows supplemented with YC selected a prepartum diet higher in CP than did unsupplemented cows, although prepartum performance of cows of both parities, as a...

in order to determine the hygiene indices of bathing water, and it's water quality, a survey and laboratory analysis was recently undertaken on 34 outdoor public swimming pools out of a total 126 in tehran metropolitan area according to simple random sampling without replacement. this survey revealed remarkable evidence of waver bacterial contamination at heavy bather load time. examined water ...

The study assessed the optimum incorporation rate of Borassus aethiopum (Ba) ripe fruits’ dried pulp in laying hens’ feed. So, 72 Isa Brown hens 37-week-old were allotted into 9 groups 8 each. Then, 3 control diets including 60% yellow corn (60%YC), 55.2% (55.2%YC) and white (60%WC) formulated. Additionally, 6 test made by substituting 5%; 7.5%; 10%; 12.5% 15% 60%WC Ba pulp...

The non-seasonal stratification variability in the upper 400 m of Yucatan Channel (YC) and its relationship with Loop Current System is studied based on analysis long-term timescales not yet resolved observational studies. Daily outputs from a 22-year free-running simulation performed HYbrid Coordinate Ocean Model were used, modes squared buoyancy frequency estimated using Empirical Orthogonal ...

Traditional Chinese Medicine (TCM) therapies should be tailored according to the different syndrome types. In order to identify the relationship between the TCM Yin-cold (YC) or Yang-heat (YH) syndrome types and the EGFR gene status, we prospectively studied 310 NSCLC patients. TCM YH or YC was diagnosed by three TCM experts. TCM symptoms and signs were entered into a binary cluster analysis. T...

PURPOSE The synthetic compound 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole (YC-1) reduces the protein stability of hypoxia-inducible factor (HIF)-1α and can serve as a potential anticancer agent. Our previous study elucidated that YC-1 decreased the protein level of HIF-1α and inhibited cell proliferation under normoxic conditions. In the present study, we explored the inhibitory effect of Y...

Nitric oxide (NO), the physiological activator of soluble guanylyl cyclase (sGC), induces inhibitory effects on platelet activation via elevation of cGMP levels and stimulation of the cGMP-dependent protein kinase. YC-1, a benzylindazole derivative, was shown to activate sGC in intact platelets, resulting in inhibition of platelet aggregation. In a previous study, we demonstrated that YC-1 not ...