A microfluidic system to determine hydrogen peroxide (H(2)O(2)) in individual HepG2 cells based on the electrokinetic gated injection was developed for the first time. A home-synthesized fluorescent probe, bis(p-methylbenzenesulfonate)dichlorofluorescein (FS), was employed to label intracellular H(2)O(2) in the intact cells. On a simple cross microchip, multiple single-cell operations, includin...

Since the start of COVID-19 outbreak, more than four million people have died this disease. Given its ability to provide a precise response, mass spectrometry-based proteomics could represent useful tool study pathology. To end, an untargeted nLC-ESI-MS/MS-based method characterise SARS-CoV-2 proteins, including possible variants, and investigate human saliva plasma proteome in single analysis ...

background: more than 36 % of the total population of iran consists of young people aged 15 to 25 yr. recent studies show that this age group has the highest rate of serious health problems. youth participatory studies on youth health priority have shown that mental health is one of the most important priorities in youth health. aim to assessing the mental health needs of youth we conducted a p...

If n is a nonnegative integer, then denote by ∂H the space of all complex valued functions f defined on D such that f, f , f , . . . , f (n) belong to H∞, with the norm

background: free-living amoebae have various genera that are found in several environmental niches such as soil, freshwater, dust, seawater and hot springs. most of free-living amoebae are normally harmless to humans. however, some such as acanthamoeba and also naegleria fowleri , balamuthia manderillaris and sappinia are identified as opportunistic and pathogenic amoebae that can cause eye dis...

Leukocytes from patients with acute granulocytic leukemia (AGL), acute monocytic leukemia (AMoL) and blastic crisis of chronic granulocytic leukemia (BC) were incubated with serine-U-C’4 or aspartic acid-U-C’4. The metabolism was followed by determination of radioactivity of CO , lipids, proteins, organic acids, and nucleotides. Leukemic leukocytes in AGL, AMoL, and BC exhibit high serine utili...

Objective: Sufficient intakes of docosahexaenoic acid (DHA) via breast milk are required for optimizing visual and neural development at early stages of life. Little or no information is available on DHA intakes and levels found in breast milk in Iranian women and surrounding regions. In this study we measure the DHA in the breast milk of lactating Iranian women from low and high – fish-eating ...

Peripheral blood leukemia cells from patients with acute monoblastic leukemia (AMoL) were tested for killer cell activity against target cells that detected natural killer cell-mediated or monocyte-mediated spontaneous cytotoxicity. The fibrosarcoma cell line Wehi 164, pretreated with actinomycin D to induce susceptibility to lysis, specifically detects the activity of unstimulated human monocy...

In this issue, Zou et al. report that vitamin C abrogated the ability of bortezomib (PS-341, Velcade) to induce apoptosis, G2-M arrest, and cleavage of caspase 8, caspase 3, and poly(ADP-ribose) polymerase and to augment tumor necrosis factor–related apoptosis-inducing ligand–induced apoptosis in various human cancer cell lines (1). Moreover, vitamin C suppressed bortezomib-mediated inhibition ...

entrepreneurship is very important in order to creating jobs for the unemployed and educated youth. as regards educated youth have fewer tendencies to self-employment and investment in this context. therefore this study was performed with the objective investigating personality skills of entrepreneurial of rural youth and suggest solutions for strengthen these skills in gonbad-e-kavous county. ...