Uncoupling protein-2 (UCP2) regulates insulin secretion and may play an important role in linking obesity to type 2 diabetes (T2D). Previous studies of the role of the UCP2 promoter -866G/A single nucleotide polymorphisms (SNP) in T2D have given opposite results. We tested the distribution of the -866G/A SNP in 746 T2D patients and 327 healthy unrelated Caucasians from Italy. We also tested for...

PURPOSE To determine the effect of inhibition of insulin-like growth factor-IR (IGF-IR) signaling with an antibody to the IGF-IR, A12, in conjunction with androgen withdrawal on prostate cancer progression in a human prostate xenograft model, LuCaP 35. EXPERIMENTAL DESIGN LuCaP 35 was implanted s.c. in severe combined immunodeficient mice. At the time of castration, mice were randomized to on...

In this paper we construct a moduli space for marked rational elliptic surfaces of index two as non-complete toric variety dimension nine. We also compactifications space, which are obtained quotients A12 by an action Gm3.

OBJECTIVE Activation of the peroxisome proliferator-activated receptor-gamma (PPARgamma) improves insulin sensitivity and exerts antiatherogenic effects. A common alanine for proline substitution at codon 12 in the PPARG2 gene is related to lower receptor activity. Studies suggest that the A12 allele is associated with reduced risk of type 2 diabetes; however, data on the risk of coronary heart...

In mice with spontaneous mutations in transcription factors Prop-1 or Pit-1, the pituitary fails to produce prolactin (PRL), GH and TSH, and numbers of hypothalamic PRL-regulating dopaminergic (DA) neurons (area A12) are reduced by more than 50%. A normal neuronal population can be maintained in these mutants by PRL treatment of neonates, but not of adults. Targeted disruption of the PRL struct...

The influence of organic matter chemistry on the sorption of diuron to soils collected from a small (2 ha) field was investigated. Organic carbon-normalized sorption coefficients (KOC), determined by batch sorption, varied between 405 and 598 Lkg amongst 10 A11 horizons, and between 547 and 975 Lkg amongst 10 matching A12 horizons. In all cases KOC was greater for the A12 horizon than the corre...

Foot-and-mouth disease virus structural protein VP1 elicits neutralizing and protective antibody and is probably the viral attachment protein which interacts with cellular receptor sites on cultured cells. To study the relationships between epitopes on the molecule related to neutralization and cell attachment, we tested monoclonal antibodies prepared against type A12 virus, isolated A12 VP1, a...

Sequences of amino acids at the N-termini of virus proteins VP1, VP2, and VP3 were determined for foot-and-mouth disease virus types A12 strain 119, O1Brugge and C3Resende. In the polyacrylamide gel electrophoresis system used to purify the proteins, VP3 migrated faster than VP1 or VP2; and in the virion, VP3 could be cleaved by trypsin into VP3a and VP3b. The N-terminal amino acids for each of...

SYK tyrosine kinase has emerged as a master regulator of cellular resistance to oxidative stress (OS) by mediating the activation of the anti-apoptotic nuclear factor kappaB and phosphatidylinositol-3 kinase/AKT pathways after OS exposure. Here, we present unprecedented experimental evidence that polo-like kinase 1 (PLK1) is the upstream regulator of SYK in B-lineage acute lymphoblastic leukaem...

The influence of organic matter chemistry on the sorption of diuron to soils collected from a small field (2 ha) was investigated. Organic carbon-normalized sorption coefficients (K ), determined by batch OC sorption, varied between 405 and 598 L kg amongst 10 A11 horizons and between 547 and 975 L kg amongst 1 1 10 matching A12 horizons. In all cases K was greater for the A12 horizon than the ...