BACKGROUND Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy characterized by abundant granulocytic myeloid-derived suppressor cells (G-MDSC = CD45+/Lin-/CD33+/CD11b+/CD15+), which infiltrate tumors and suppress anti-tumor immunity. We have previously demonstrated in a murine model of PDAC that zoledronic acid (ZA) depletes G-MDSC resulting in decreased tumor growth and improv...

The zonula adherens (ZA) of epithelial cells is a site of cell-cell adhesion where cellular forces are exerted and resisted. Increasing evidence indicates that E-cadherin adhesion molecules at the ZA serve to sense force applied on the junctions and coordinate cytoskeletal responses to those forces. Efforts to understand the role that cadherins play in mechanotransduction have been limited by t...

Breast cancer is a very common diagnosis in women; approximately 30% of patients with breast cancer will develop bone metastases. In addition, breast cancer patients experience adjuvant treatment related bone loss. Bisphosphonates (BPs) are the standard of care for maintaining bone health in patients with cancer. The purpose of this paper is to review the evidence on the use of zoledronic acid ...

Tomislav Badel1, Kata Rošin-Grget2, Ladislav Krapac3, Miljenko Marotti4 Zavod za stomatološku protetiku Stomatološki fakultet Sveučilišta u Zagrebu 10000 Zagreb, Gundulićeva 5 Katedra za farmakologiju Stomatološki fakultet Sveučilišta u Zagrebu 10000 Zagreb, Šalata 11 Poliklinika za reumatske bolesti, fi zikalnu medicinu i rehabilitaciju “Dr. Drago Čop” 10000 Zagreb, Mihanovićeva 3 Klinički zav...

V članku je predstavljen sistem za gradnjo globinskih panoramskih slik s postopkom mozaičenja standardnih slik zajetih z eno kamero. Zaradi odmika optičnega centra kamere iz sredǐsča vrtenja sistema, lahko z eno kamero zajamemo paralakso gibanja, ki omogoča stereo rekonstrukcijo. Panoramske slike ustvarimo tako, da rotacijsko roko vrtimo za kot, ki ustreza premiku za eno kolono zajete slike. Iz...

Introduction Bisphosphonates are widely used in metastatic cancer such as prostate and breast cancer, and their nephrotoxic effects have been established previously. In this study we aimed to evaluate both the nephrotoxic effects of zoledronic acid (ZA) and the protective effects of vitamin E (Vit-E) on this process under light and electron microscopy. Material and methods A total of 30 male ...

Povzetek. Načrtovalski vzorci so za izkušene načrtovalce nepogrešljivo orodje pri razvoju objektno orientirane programske opreme. Izkušnje, zajete v vzorcih, se preslikujejo v načrt programske opreme skozi realizacijo načrtovalskega vzorca. Realizacija nadgrajuje načrt s spremembami v strukturi objektov in v njihovi medsebojni komunikaciji. Vsi načrtovalski vzorci dopuščajo množico različnih re...

The aim of this study was to evaluate the effects on new bone formation of autogenous blood alone or in combination with zoledronic acid (ZA), a β-tricalcium phosphate (β-TCP) graft or ZA plus a β-TCP graft placed under titanium barriers. For this purpose, eight adult male New Zealand white rabbits were used in the study, each with four titanium barriers fixed around four sets of nine holes dri...

Autori u članku procjenjuju funkciju potražnje za novcem u Hrvatskoj za novčane agregate M1 i M1a unutar vektorske autoregresije. Potražnja za novčanim saldom se povećala nakon uvođenja antiinflacijskog stabilizacijskog programa godine 1993. Monetarnu politiku je ograničila liberalizacija deviznog tržišta i deviznog tečaja, očekivana inflacija je bila smanjena, a kućanstva su zamijenila ukinutu...