BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) due to Leishmania major is highly prevalent in Tunisia and is transmitted by a hematophagous vector Phlebotomus papatasi (P. papatasi). While probing for a blood meal, the sand fly injects saliva into the host's skin, which contains a variety of compounds that are highly immunogenic. We recently showed that the presence of anti-saliva antibodies...

background: zoonotic cutaneous leishmaniasis (zcl) is a polymorphic disease which may show various clinical manifestations. although genetic variability of the parasite is suggested to be one of the factors influencing clinical manifestations in leishmaniasis, no data exist regarding genetic polymorphism of leishmania major . therefore, determination of genetic variation within the species of l...

background: geographical distribution of zoonotic cutaneous leishmaniasis (zcl) has continuously been extended in recent years in iran. the beiza district is one of the newly-emerged endemic foci of zcl in southern iran. the main aim of the present study was to detect the vector(s) of zcl in this area. methods: to detect the fauna and vectors of zcl in this district, sand flies were caught usin...

Background and aim: Isfahan is one of the most important endemic areas of zoonotic cutaneous leishmaniasis (ZCL) in Iran. The objective of this study was to present different clinical pictures of ZCL and to identify the responsible Leishmania species using polymerase chain reaction (PCR). Materials and methods: This cross-sectional, descriptive-analytic study was performed from September 2006 t...

background: zoonotic   cutaneous leishmaniasis (zcl) is an increasing health problems in many rural areas of iran. the aim of this study was to introduce a new alternative rodenticide to control the reservoirs of zcl, its effect on the vector density and the incidence of the disease in hyperendemic focus of esfa­han county, central iran. methods: the study was carried out from january 2011 to j...

abstract background: zoonotic cutaneous leishmaniasis (zcl) is one of the most important vector-borne diseases in iran. wild rodents play as a reservoir. the main aim of this study was to determine spatial analyses of the relationship between rodent’s active burrows and incidence of zcl in golestan province, north east of iran . methods : the cross-sectional study was conducted in 59 rural dist...

BACKGROUND Zoonotic cutaneous leishmaniasis is a growing health problem in many rural areas of Iran. Rhombomys opimus, the great gerbil, is the main animal reservoir of ZCL in the northeast and central part of Iran. The aim of the current study was to evaluate the rodenticidal effect of Coumavec® (a mixture of Coumatetralyl 0.5% and Etofenprox 0.5%) on R. opimus under laboratory condition. ME...

BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) is a neglected tropical disease prevailed in many rural areas of 17 out of 31 provinces in Iran. The main vector of the disease is Phlebotomus papatasi and the causative agent is Leishmania major in ZCL foci of Iran. In the current study we investigated the validity of accessory glands secretions as an indicator to recognize parous from nullipar...

BACKGROUND Zoonotic Cutaneous Leishmaniasis (ZCL) is endemic in many parts of Iran. Recently its incidence is considerable in different parts of Jahrom district, in Fars Province, southern Iran. The aims of our study were to investigate the prevalence of leishmania infection, and identify and characterize the Leishmania species present, among the rodents by molecular methods in a new endemic fo...

BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) due to Leishmania major is increasing in many parts of Iran. This disease originally is a disease found in gerbils. Leishmania parasites are transmitted by sandflies that live and breed in gerbil burrows. Nested PCR amplified Leishmania ITS1-5.8S rRNA gene in both main reservoir host "Rhombomys opimus" and in the "Phlebotomus papatasi" main vect...