A reliable and sensitive liquid chromatography-tandem mass spectrometric method was developed for the simultaneous quantitative determination in cereals of the Fusarium mycotoxins HT-2 toxin, T-2 toxin, deoxynivalenol, nivalenol and zearalenone, as well as the modified metabolites 3-acetyl-deoxynivalenol, α-zearalenol, β-zearalenol, deoxynivalenol-3-glucoside, HT-2-3-glucoside, nivalenol-3-gluc...

The study determined the occurrence of deoxynivalenol (DON), zearalenone (ZEN) and their metabolites in staple cereals from Southwest Nigeria. Sixty composite samples maize, sorghum millet were evaluated for DON, ZEN masked forms; 3-acetyldeoxynivalenol (3Ac-DON), 15-acetyldeoxynivalenol (15Ac-DON), ?-zearalenone (?-ZEL) ?-zearalenone (?-ZEL). Deoxynivalenol did not co-occur with contrast to pr...

Introduction: Zearalenone is a mycotoxin compound produced mainly by the Fusarium species of fungi which is present in several types of foods. T he purpose of this study was to determine the zearalenone in raw animal origin food produced in North-West of Iran . Materials and methods: From June to December 2012, a total of 210 samples (containing 70 raw milk, 70 meat and 70 liver) were obtai...

BACKGROUND The aim of this study was to investigate the in vitro effects of the Fusarium fungus-derived mycotoxin, zearalenone and its derivatives alpha-zearalenol and beta-zearalenol on motility parameters and the acrosome reaction of stallion sperm. Since the toxic effects of zearalenone and its derivatives are thought to result from their structural similarity to 17beta-estradiol, 17beta-est...

Ten metabolites of Fusarium species (butenolide, diacetoxyscirpenol, equisetin, fusaric acid, gibberellic acid, moniliformin, NRRL 6227 peptide, T-2 toxin, vomitoxin, and zearalenone) were added to the drinking water of mice to determine whether they were consumed or refused. Of the 10, only the trichothecenes--diacetoxyscirpenol, T-2 toxin, and vomitoxin--were refused. Refusal of 2 mg of the t...

Farm animals are exposed to zearalenone through the feed because of the widespread occurrence of this mycotoxin in cereals and clinical reproductive disorders due to mycotoxin effects are often reported in farm animal species. This review describes the metabolism, the mechanistic aspects, the clinical reproductive symptoms and the in vitro effects on functional parameters of oocytes and sperm c...

By replacement of an acetate with propionate through organic synthesis a range of zearalenone analogues were prepared. As key steps in the synthesis of the analogues we used the Noyori hydrogenation of methyl acetoacetate followed by Frater alkylation of the enantiomeric 3-hydroxybutyrates. This converted the second acetate to a propionate. Through the derived alkyne, chain extension led to 3-m...