BACKGROUND The study was carried out to assess the gastroprotective effect of the zinc (II) complex against ethanol-induced acute hemorrhagic lesions in rats. METHODOLOGY/PRINCIPAL FINDING The animals received their respective pre-treatments dissolved in tween 20 (5% v/v), orally. Ethanol (95% v/v) was orally administrated to induce superficial hemorrhagic mucosal lesions. Omeprazole (5.790×1...

Dithiocarbamates, with their high lipophilic character and good chelating properties, could provide stabile transition metal complexes enable these metal-based drugs to reach biological targets. Palladium(II) gold(III) complexes, due its structural similarity platinum(II)compounds, be competitive candidates for implementing developing new pharmacological agents. Herein, novel complex triammoniu...

Inspired by trinuclear Zn(II) sites in enzymatic systems, a ligand system containing three preorganized (2-pyridyl)methyl piperazine moieties anchored onto a rigid C3-symmetric triphenoxymethane platform has been developed for preorganizing three zinc ions into an environment conducive to intramolecular interaction. Zinc(II) binding by this ligand has been analyzed by means of potentiometric me...

Zinc(II) and copper(II) complexes of two new potentially pentadentate ligands based on methyl 2-aminocyclopent1-ene-1-dithiocarboxylate with pendent pyrazolyl groups (Me2pzCH2)2NC2H3RNHC5H6CSSCH3 (R ) H,Hmmecd, and R ) CH3, Hmmpcd, both having N4S donor atoms set) have been reported. The molecular structures of [Zn(mmpcd)]ClO4 (1b) and [Cu(mmpcd)]ClO4 (2b) show a distorted trigonal bipyramidal ...

Zinc(II) plays a vital role in normal cellular function as an essential component of numerous enzymes, transcription factors, and synaptic vesicles. While zinc can be linked to a variety of physiological processes, the mechanisms of its cellular actions are less discernible. Here, we have synthesized and tested a Zn(II)-activated magnetic resonance imaging (MRI) contrast agent in which the coor...

The title mononuclear zinc(II) complex, [Zn(C(10)H(15)N(3))(2)](ClO(4))(2), was obtained by the reaction of 2-acetyl-pyridine, N-methyl-ethane-1,2-diamine and zinc perchlorate in methanol. The asymmetric unit of the complex contains two independent [Zn(C(10)H(15)N(3))(2)](2+) cations and four perchlorate anions. The Zn(II) atom in each complex cation is six-coordinated by two pyridine N, two im...

A zinc(II)-dipicolylamine coordination complex selectively associates with anionic liposomes, including sterically protected PEGylated liposomes, and causes rapid leakage of encapsulated contents.

The Schiff base ligand, 4-chloro-2-(quinolin-8-yliminomethyl)-phenol (HClQP), reacts with ZnCl2.4H2O to afford a binuclear zinc(II) complex (1), which has been synthesized and characterized by IR, ESI-MS, elemental analysis and single crystal X-ray diffraction analysis. In complex (1), the two zinc atoms are in a five-coordinated tetragonal pyramidal geometry and a four-coordinated tetrahedral ...

The three major eukaryotic RNA polymerases contain zinc. The presence of zinc cations bound to various polymerase subunits was determined by early work describing the purification of eukaryotic RNA polymerases, including RNA polymerase I (RNAP I), the enzyme that produces three of the four rRNAs. These pioneer studies also showed that zinc is required for the activity of various eukaryotic RNA ...