Alzheimer's disease (AD) is the most common form of dementia in the elderly. Hallmark AD neuropathology includes extracellular amyloid plaques composed largely of the amyloid-β protein (Aβ), intracellular neurofibrillary tangles (NFTs) composed of hyper-phosphorylated microtubule-associated protein tau (MAP-tau), and microtubule destabilization. Early-onset autosomal dominant AD genes are assoc...

Highly purified recombinant zinc-endopeptidase light chain of the botulinum neurotoxin serotype A underwent autocatalytic proteolytic processing and fragmentation. In the absence of added zinc, initially 10-28 residues were cleaved from the C-terminal end of the 448-residue protein followed by the appearance of an SDS-stable dimer and finally fragmentation near the middle of the molecule. In th...

RNA binding proteins (RBPs) are vital to the regulation of mRNA transcripts, and can alter mRNA localization, degradation, translation, and storage. Whi3 was originally identified in a screen for small cell size mutants, and has since been characterized as an RBP. The identification of Whi3-interacting mRNAs involved in mediating cellular responses to stress suggested that Whi3 might be involve...

BACKGROUND The cowpea (Vigna unguiculata L. Wap.) is an excellent source of iron and zinc. However, iron from plant sources is poorly absorbed compared with iron from animal sources. OBJECTIVES The objective of this study was to evaluate iron and zinc bioaccessibility in cowpea cultivars after processing. METHODS Zinc and iron bioaccessibilities in cowpea samples were determined based on an...

Zinc released from excited glutamatergic neurons accelerates amyloid beta (Abeta) aggregation, underscoring the therapeutic potential of zinc chelation for the treatment of Alzheimer's disease (AD). Zinc can also alter Abeta concentration by affecting its degradation. In order to elucidate the possible role of zinc influx in secretase-processed Abeta production, SH-SY5Y cells stably expressing ...

Ferrous metallurgy enterprises continuously fill dumps with steelmaking and blast furnace sludge high zinc content. Sludge occupying significant territories of is not involved in production harms the environment. Since leads to formation deposits furnace, manufacturers cannot involve this sinter processing. In addition, working can lead problems such as decrease iron content sinter, productivit...

Guthrie GJ, Aydemir TB, Troche C, Martin AB, Chang S, Cousins RJ. Influence of ZIP14 (slc39A14) on intestinal zinc processing and barrier function. Am J Physiol Gastrointest Liver Physiol 308: G171–G178, 2015. First published November 26, 2014; doi:10.1152/ajpgi.00021.2014.—ZIP14 is a zinc transport protein with high expression in the small intestine and liver. Zip14 is upregulated during endot...

Introduction. Silicon-zinc-boron-containing glycerohydrogel substance is considered as a pharmaceutical for the new drugs creation with antimicrobial action local, external and intravaginal use. Standardization validation of methods determining quality parameters corresponding substances one stages introducing pharmacologically active compounds into practice. Aim. Determine silicon-zinc-boron-c...

A role for metallothionein in intestinal zinc absorption has been the subject of considerable debate. If metallothionein affects zinc absorption, then those factors that induce metallothionein synthesis (e.g., heavy metals, hormones) should alter zinc absorption and homeostasis. The present studies used metallothionein transgenic mice (overexpressing) and metallothionein knockout mice (no expre...