Here, we investigated the role of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on angiogenesis using human umbilical vein endothelial cells (HUVECs). Zerumbone inhibited HUVECs proliferation, migration and tubule formation, as well as angiogenic activity by rat aorta explants. In particular, zerumbone inhibited phosphorylation of vascular endothelial growth factor recep...

Zerumbone (ZER) is derived from Zingiber zerumbet smith from the Zingiberaceae family. It has been shown to have anti-cancer and apoptosis-inducing properties against various human tumour cells. The aim of our study was to assess the genotoxic effects of ZER in cultured human peripheral blood lymphocytes, Chinese Hamster Ovary (CHO) cells and rat bone marrow polychromatic erythrocytes (PCEs) us...

Zingiber zerumbet (L.) Sm. is a well known medicinal plant employed to cure various diseases. The Current study provides a detailed summary of pharmacognostical and phytochemical characters of rhizome to give clear standards for identification of the drug. The study revealed the presence of the oil cells in cortex and central cylinder region containing yellow to orange coloured oleo-resin is th...

The essential oils of ginger (Zingiber officinale) and turmeric (Curcuma longa) contain a large variety of terpenoids, some of which possess anticancer, antiulcer, and antioxidant properties. Despite their importance, only four terpene synthases have been identified from the Zingiberaceae family: (+)-germacrene D synthase and (S)-β-bisabolene synthase from ginger rhizome, and α-humulene synthas...

One of the Zingiber species that has long been used as traditional medicine by local Indonesian people is lempuyang (Zingiber ssp.). In its use medicine, it more often than other types lempuyang, namely gajah zerumbet (L.) Roscoeex Sm.). Therefore, this study focused on Sm. Most biological activities reported for plant are attributed to phenolic contents and volatile principles. Hence, a detail...