Based on the knowledge that a cured infection protects the individual from re-infection, the development of a vaccine to prevent leishmaniasis has been a goal for nearly a century. Indeed, it is generally believed that after healing of leishmaniasis, sterile cure is never achieved and that few residual living parasites will remain sequestered within some host cells that offer them a safe shelte...

Background Leishmaniasis as an emerging and reemerging disease is increasing worldwide with high prevalence and new incidence in recent years. For epidemiological investigation and accurate identification of Leishmania species, three nuclear and mitochondrial genes (ITS-rDNA, Hsp70, and Cyt b) were employed and analyzed from clinical samples in three important Zoonotic Cutaneous Leishmaniasis (...

conclusions this is the first molecular report on parasite infection of both vector (p. papatas) and reservoir (t. indica) to l. major from this area. therefore, the population of both sandflies and rodents should be reduced using control methods. background leishmaniais which is one of the six most important tropical diseases in the world are in iran in 3 forms. cutaneous leishmaniasis (cl) is...

introduction: zoonotic cutaneous leishmaniasis(zcl) is one of the most important parasitic diseases in iran and common in rural districts of half of the 30 provinces of the country. in recent years, zcl has become a serious and increasing public health problem in yazd province. following the epidemic of cl in khatam county of yazd province, this study was carried out to determine the animal res...

BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) is an expanding disease and public health problem in Iran. In the current study, natural Leishmania infection rate and seasonal fluctuation of the infection in Rhombomys opimus population of a hyperendemic focus of ZCL in Iran was investigated. METHODS The study was conducted from October 2006 to October 2008 in Esfahan Province, central part ...

Zoonotic cutaneous leishmaniasis (ZCL) caused by Leishmania (L.) major parasites represents a major health problem with a large spectrum of clinical manifestations. Psammomys (P.) obesus and Meriones (M.) shawi represent the most important host reservoirs of these parasites in Tunisia. We already reported that infection prevalence is different between these two rodent species. We aimed in this ...

BACKGROUND Zoonotic cutaneous leishmaniasis (ZCL) is polymorphic disease that may show various clinical manifestations. OBJECTIVES This study investigates the determination of genetic variation within the species of Leishmania major isolates from new cases in Chabahar, a port city in Southeast Iran (situated at the Iran-Pakistan border). Migration in this region indicates that leishmaniasis i...

background: zoonotic cutaneous leishmaniasis (zcl) is a neglected disease with public health importance that is common in many rural areas of iran. in recent years, behavioral resistance and/or bait shyness against the common rodenticide among reservoir hosts of zcl have been reported. the aim of this study was to evaluate the effectiveness of klerat® and zinc phosphide against natural reservoi...

cutaneous leishmaniasis (cl) remains a serious public health concern in kerman province, eastern iran. this study was aimed to conduct a comprehensive review and highlights various aspects of cl in the province of kerman.this article mainly focuses on the studies published in the past 26 years on cl in the province. current data for the present status were obtained through the provincial health...

conclusions the widespread distribution of l. major parasites in human suggests not only t. indica was the main reservoir but also other rodents and mammalian hosts might be the reservoir hosts of zcl in the region. molecular and phylogenetic analyses confirmed the strength of haplotype variation maintaining the circulation of leishmania species in their reservoir hosts. results leishmania majo...