The formation of zwitterionic adducts between neutral nucleophiles such as NMe(3) and PMe(3) with neutral electrophiles such as methyl vinyl ketone (MVK) has been studied with a wide variety of theoretical methods. It has been found that hybrid density functional methods such as B3LYP are not capable of describing these zwitterionic structures as minima on the potential energy surface. This is ...

The structures of isolated alkaline earth metal cationized amino acids are investigated using infrared multiple photon dissociation (IRMPD) spectroscopy and theory. These results indicate that arginine, glutamine, proline, serine, and valine all adopt zwitterionic structures when complexed with divalent barium. The IRMPD spectra for these ions exhibit bands assigned to carboxylate stretching mo...

In this work, small-angle X-ray scattering (SAXS) studies on the interaction of the phenothiazine cationic compounds trifluoperazine (TFP, 2-10 mM) and chlorpromazine (CPZ, 2-10 mM) with micelles of the zwitterionic surfactant L-alpha-lysophosphatidylcholine (LPC, 30 mM), at pHs 4.0 and 7.0, are reported. The SAXS results demonstrate that, upon addition of both phenothiazines, the LPC micelle o...

Morphological selection of the self-assembled nanostructure of zwitterionic porphyrins between nanorod and nanosheet by the small displacement of the peripheral anionic position is demonstrated based on the J-aggregates of zwitterionic porphyrin isomers, meso-tetrakis(5-sulfonatothienyl)porphyrin diacid and meso-tetrakis(4-sulfonatothienyl)porphyrin diacid.

A new zwitterionic monolayer film of sulfobetaine was constructed by grafting novelly designed N,N-dimethyl (beta-hydroxyethyloxyethyl) ammonium propanesulfonate (DHAPS) to hydroxyl groups of glass in the presence of hexamethylene diisocyanate (HDI) as a coupling agent and dibutyltin dilaurate (DBTDL) as a catalyst. Experiments of blood adhesion proved that the zwitterionic film possessed excel...

A novel zwitterionic near-infrared (NIR) dye, ZWCC, has been designed and synthesized. It shows significantly enhanced photostability and chemical stability compared to the existing zwitterionic NIR dye. In addition, the feasibility of labeling ZWCC with biological ligands was investigated and used in live cell imaging applications.

In contrast to currently marketed fluoroquinolones, which are zwitterionic, delafloxacin is an investigational fluoroquinolone with an anionic character that is highly active against Gram-positive bacteria. We have examined the effect of acidic pH on its accumulation in Staphylococcus aureus and in human THP-1 cells, in parallel with its activity against extracellular and intracellular S. aureu...

Zwitterionic polymers are classical antifouling but they require specialized monomers that have cationic and anionic charges integrated into a single monomer. Herein, we show pseudo-zwitterionic copolymers synthesized from mixture of 2 each having opposite polarity has excellent antibiofilm efficacy. We discovered new mixed-charge copolymer brush (#1-A) oppositely charged monomers, the SPM (3-S...

The nucleosyl amino acid (NAA)-modification of oligonucleotides is introduced, which enables the preparation of oligonucleotides with zwitterionic backbone structures. It is demonstrated that partially zwitterionic NAA-modified DNA oligonucleotides are capable of duplex formation with native polyanionic counterstrands and show retained sensitivity towards base-pairing mismatches.

Cationic and zwitterionic boryl bromide species and a borenium-boryl bromide cation have been synthesised which represent new N-donor stabilised cationic boron compounds with β-diketiminate ligands. The unexpected borenium-boryl bromide results from a head-to-tail dimerisation of the corresponding zwitterionic boryl bromide accompanied by proton migration. The electronic nature of these new spe...