We optimized the modulation of drug resistance by the irreversible augmentation of cytotoxicity of coincubating vinblastine (VNB) with VP16 and the reversible increase in cytotoxicity of coincubation of verapamil (VPL) with VNB and VP-16. VPL was administered as a loading dose (i.v.) (0.15 mg/kg) and then administered as a constant infusion (0.005 mg/kg) over 6 days. 24 h after verapamil, VNB 2...

Page 3. It is not entirely clear what causal model the authors have in mind, and specifically whether they consider smoking and air pollution as mediators or confounders of the association between SES and respiratory health. In paragraph two, page 1, they imply mediation (â##â#¦strongly influenced by SES..â##) but in paragraph three, confounding is implied (â##....competing factorsâ#¦â##). This...

The aggregation of the â-peptide into amyloid is a key pathological event in Alzheimer’s disease. This process (â-amyloidosis) involves the conversion of soluble random coil, R-helical or â-sheet conformations into insoluble, aggregated â-pleated sheet structures. The pH is a significant extrinsic factor that influences â-amyloidosis, which must be related to the presence of ionizable groups in...

Studies on GSK3¥â expression in the kainate induced excitototoxic hippocampal injury model of mice Jung Hoon Lee Department of Anatomy Graduate School Seoul National University Glycogen synthase kinase 3¥â (GSK3¥â) is believed to play important roles in the regulation of synaptic plasticity, cell survival and circadian rhythms in the mature CNS. However, although several studies have been focus...

â  pathology of theses in the department of arabic language and literature in university of isfahan in its half a century activities â  (a descriptive – analytical study) â â â  somayeh hasan alian * â  sayyedmohammadreza ibnorrasool ** â  â  considering the importance of understanding the history of researches in every field and the necessity of the pathology of these researches to enhance k...

To determine the type of mutation induced by 8-hydroxyguanine in a mammalian system, we examined the mutations induced by a synthetic i -I la-ruv protooncogene containing 8-hydroxyguanine in the second po sition of codon 12 (GGC) in NIH3T3 cells. Transaction of this gene significantly increased the number of transformed foci. The c-Ha-r<w gene present in these foci was analyzed by the polymeras...

 The foreign exchange market (FX market) accounts for 40% of the total volume of the world’s e-commerce by its own. Based on statistics, sometimes up to 90 per cent of the traders lose their total capital in this market just within six months to one year and leave this market. The probability of loss in the FX market can be estimated by probability theory. The present paper intends to demonst...

Thirteen patients with metastatic breast carcinoma were given injec dons of 50—1593@ag of †̃311-monoclonal antibody (MAb) B6.2 immuno globulin G and F(ab')@for pharmacokinetic evaluation and radioimmu noimaging. Blood clearance of the †̃31I-MAb-B6.2 was biphasic. The mean half-times (t@, t@.,)for the immunoglobulin G were 33 ±1.7 and 20.9 ±11.0 h, respectively. The t@ for the F(ab'>@was 1...

â â â  moral values of shanfara in , lamyat- alarab ode â  â  somayeh kazemi * â  jafar delshad ** â  â  in this descriptive-analytic study, the researchers aimed to study the verses of lamyat- al arab and examine the moral values and mental pains which made the poet shanfara express such values. â  this survey has been affected by a hadith that indicates the tendency of the poet to the moral v...

APEC Study Centre, University of Auckland, Auckland, New Zealand     Abstract:   One of the key sets of questions underlying Asia Pacific economic cooperation over the last decade has been over the nature and form of the regional trade architecture that would gradually emerge from the turmoil of the Asia-Pacific “noodle bowl” of bilateral and plurilateral FTAs, and how that architecture...