T cells expressing checkpoint receptors PD-1, TIM-3 etc., are potential targets for monoclonal antibody immunotherapy in multiple myeloma (MM). However, cell compartment includes different subsets, and their dysregulation following anti-checkpoint therapy can lead to the development of adverse events. The aim this study was evaluate activation markers – homeostatic cytokine transcription factor...

Doogh is the most popular and commonly consumed yoghurt-based Iranian drink. The aim of this study was to investigate the antibacterial effects of Ziziphora clinopodioides essential oil (ZEO) at 0.10 and 0.20% concentrations, nisin at 250 and 500 IU mL-1, and their combination against Salmonella typhimurium and Staphylococcusaureus in doogh during storage at 4 ˚C for  9 days. Nine batches were ...

The aim of this trial was to evaluate fatty acid profile of meat from lambs fed on diets containing 0, 12.5 and 25.0% mulberry hay as a substitute for the concentrate. Twenty-four feedlot Ile de France lambs (average weight of 15kg and average age of 60 days) were randomized to receive the different diets and slaughtered at 32kg body weight. Increases were observed in the concentrations of the ...

In this research, essential oils (EOs) were extracted through steaming from aerial parts of three plants: basil (Ocinum basilicum L.), peppermint (Mentha piperita L.) and oregano (Origanum vulgare form Sibiu County, Romania. The GC-MS analysis indicated that eugenol apiol the major compounds in EO. Timol, ɣ-terpinene, p-cymene volatile oil menthol methone main components first 48 h analysis, EO...

Intermetallic alloy is a combination consists of two metal compounds or more. One intermetallic that can be used nickel. Nickel corrosion resistant and withstands high temperature. for application on aircraft components such as turbin gas engine operate in temperature extreme environment. This study conducted to find out the changes micro structure hardness NiAlTi material added by germanium 1,...

The article presents the results of studying radio protective properties alfalfa extract (dietary supplement "Erakond"). A decrease in iron content macrophages red pulp spleen was found experimentally using models experimental radiation pathology induced by ɣ-irradiation white rats a single dose 4 Gy at rate 1.7 Gy/min. mechanisms pathological processes acute pathology, leading to endogenous sy...

Sepsis is one of the major causes of death reported in intensive care units. Acute kidney injury (AKI) and hypotension are important in the pathogenesis and mortality of systemic inflammatory response (SIR). Sesamol delays mortality in sepsis; however, its effects on AKI and hypotension and the role of peroxisome proliferator-activated receptor-ɣ (PPAR-γ) activation have not been established. W...