Background: Thymus persicus is one of the Iranian endemic medicinal plants, that its decoction and various products have plenty of food and pharmaceutical uses. Objective: Evaluation of T. persicus products metabolite contains and determination of the best antioxidant, anti-diabetic and anti-Alzheimer extract. Methods: Samples total phenolic, flavonoid and tannin contents were determined by F...

Background. This study sought to investigate the antidiabetic and antihypertensive mechanisms of cocoa (Theobroma cacao) bean through inhibition of α-amylase, α-glucosidase, angiotensin-1 converting enzyme, and oxidative stress. Methodology. The total phenol and flavonoid contents of the water extractable phytochemicals from the powdered cocoa bean were determined and the effects of the extract...

the purpose of this investigation was to determine the antioxidant potentials and anti-glucosidase activities of six tropical medicinal plants. the levels of phenolic constituents in these medicinal plants were also quantified and compared. antioxidation potentials were determined colorimetrically for scavenging activities against dpph and no radicals. metal chelating assay was based on the mea...

A series of 3-styrylchromone derivatives (4-20) were synthesized and the structure-activity relationships for α-glucosidase inhibition and antioxidant activities were analyzed. Among the synthesized compounds, compounds 15 and 20, which contain a catechol moiety, showed both potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity (15: EC₅₀=17 µM; 20: EC₅₀=23 µM) and α-gluco...

BACKGROUND Brucea javanica (B. javanica) seeds, also known as "Melada pahit" in Indo-Malay region are traditionally used to treat diabetes. The objective of this study was to determine antidiabetic, antioxidant and anti-inflammatory effects of B. javanica seeds on nicotinamide (NA)-streptozotocin (STZ) induced type 2 diabetic (T2D) rats and to analyze its chemical composition that correlate wit...

Five new oleanane-type saponins, named ligushicosides A-E, and three known oleanane-type saponins were isolated from the roots of Ligulariopsis shichuana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-gluc...

The inhibition of enzymes involved in the breakdown of carbohydrates is considered a therapeutic approach to the management of type-2 diabetes. This study sought to investigate the effects of essential oil from clove bud on α-amylase and α-glucosidase activities. Essential oil from clove bud was extracted by hydrodistillation, dried with anhydrous Na2SO4 and characterized using gas chromatograp...

BACKGROUND Extracts from Polygonum senegalensis (Polygonaceae) and Pseudocedrela kotschyi (Meliaceae) are two important traditionally used medicinal plants in rural Benin to treat many diseases and notably type 2 diabetes. The aim of the study was to investigate the α-glucosidase inhibition, antioxidant and antibacterial activities of those plants extract: Polygonum senegalensis leaves, and Pse...

BACKGROUND In the present study, we tested a 50% ethanolic extract of Orthosiphon stamineus plants and its isolated bioactive compound with respect to their α-glucosidase and α-amylase inhibitory activities. METHODS Bioactive flavonoid sinensetin was isolated from 50% ethanolic extract of Orthosiphon stamineus. The structure of this pure compound was determined on the NMR data and the α-gluco...

the effects of allium sativum on yogurt formation and subsequent storage (4°c, up to 28 days) on proteolysis, microbial activity, and inhibition of α-amylase, α-glucosidase and angiotensin-i converting enzymes were investigated in vitro. allium sativum yogurt showed higher rates of ph reduction and increment of titrable acid than control during the incubation at 41°c. highest proteolysis was ob...