objective: β-thalassemia is caused by absence or reduction of β-globin chain synthesis. one of the effective therapeutic methods for this disease can be gene therapy by viral vectors. the capacity of lentiviral vectors is approximately 8 kb, we designed a 6 kb construct containing mini lcr and β-globin gene instead of lcr region. the aim of this study is to make a recombinant lentiviruses conta...

An alginate (named P1) prepared from Sargassum fusiforme has been proven to have significant anti-photoaging activity in our previous study. In this study, lyase was used obtain P1 hydrolysates with different molecular weights, and their structural characteristics were compared. Results showed that lyases could rapidly degrade the weight of slightly changed its chemical composition. Fourier tra...

The neutrinoless double β-decay is reviewed. Model independent evidence in favor of neutrino masses and mixing is briefly summarized. The data of the recent experiments on the search for 0νββ-decay are presented and some future experiments are discussed. The possible values of the effective Majorana mass, which can be predicted on the basis of the neutrino oscillation data under different assum...

background: approximately 180 mutations have been described in β-thalassemia worldwide with specific spectrum in each ethnic population. this study determines the spectrum and the frequency of β-thalassemia mutations in patients with β-thalassemia trait and sickle cell-β-thalassemia.   methods: fifteen compound heterozygous sickle cell thalassemia (sct) and 23 β-thalassemia trait patients were ...

Neutrinoless double-beta (0νββ) decay would signal violation of total lepton number conservation. The process can be mediated by an exchange of a light Majorana neutrino, or by an exchange of other particles. However, the existence of 0νββ decay requires Majorana neutrino mass, no matter what the actual mechanism is. As long as only a limit on the lifetime is available, limits on the effective ...