Understanding the dynamic behavior of nanostructural systems is important during the development of controllable and tailor-made nanomaterials. This is particularly true for nanostructures that are intended for biological applications because biomolecules are usually highly dynamic and responsive to external stimuli. In this Article, we investigated the structural and conformational dynamics of...

β-peptides are peptide-mimetics with wide biomedical and biotechnological applications. Their most peculiar feature is their readiness to fold into various secondary structures not found in natural counterparts. Furthermore, β-amino acid insertions polypeptides were provide unique features also increase enzymatic stability. This due the additional methylene group backbone, which on other hand m...

Type 1 diabetes mellitus (T1DM) is an autoimmune metabolic disorder characterized by the destruction of pancreatic β‑cells due to reactions autoreactive T‑cells and autoantibodies. The present study aimed investigate association between levels connecting peptide (C‑peptide), several biochemical immunological markers in patients with T1DM treated insulin. For this purpose, a total 5 ml venous bl...

β-amyloid hypothesis is the predominant hypothesis in the study of pathogenesis of Alzheimer's disease. This hypothesis claims that aggregation and neurotoxic effects of amyloid β (Aβ) is the common pathway in a variety of etiological factors for Alzheimer's disease. Aβ peptide derives from amyloid precursor protein (APP). β-sheet breaker peptides can directly prevent and reverse protein misfol...

The applications of supramolecular metal-peptide assemblies as catalyst or precursor have recent attracted increasing attentions. In this work, a fragment the amyloid β-peptide, NH2-KLVFF-COOH, was assembled into nanofilms with encapsulated Pd, Pt and Au nanoparticles (NPs) via one-step room temperature electron induction method. effects building block, intermolecular interaction, driving force...

We sought to evaluate the reproducibility of a liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based approach to measure the stable-isotope enrichment of in vivo-labeled muscle ATP synthase β subunit (β-F1-ATPase), a protein most directly involved in ATP production, and whose abundance is reduced under a variety of circumstances. Muscle was obtained from a rat infused with stable-isot...

INTRODUCTION In Alzheimer's disease, accumulation and pathological aggregation of amyloid β-peptide is accompanied by the induction of complex immune responses, which have been attributed both beneficial and detrimental properties. Such responses implicate various cell types of the innate and adaptive arm of the immunesystem, both inside the central nervous system, and in the periphery. To inve...

Many studies highlighted potential associations of β-casein A1 with specific human diseases and a minor digestibility milk, due to the bioactive peptide β-casomorphin 7 (BCM-7) release during digestion. Conversely, ancestral A2 variant seems be favorable trait because it is not associated BMC-7 release. The aim this work was evaluate frequencies variants in offspring previously genotyped cows i...

In the present study we attempted to correlate the structure and function of the cry11a (72 kDa) and cry4a (135 kDa) proteins of Bacillus thuringiensis var israelensis. Homology modeling and secondary structure predictions were done to locate most probable regions for finding helices or strands in these proteins. The JPRED (JPRED consensus secondary structure prediction server) secondary struct...

Accelerated molecular dynamics is used to explore the binding of Zn N-terminal fragment amyloid-β, and test performance AMBER-style forcefields. • AMBER forcefield reproduces NMR structure Zn(II) bound Aβ. Implicit solvent performs at least as well explicit in this regard. MD shows subtle difference for different modes. Free energy surface restriction size flexibility due Zn-binding. We report ...