TBP-TFIIA interaction is involved in the potentiation of TATA box-driven promoters. TFIIA activates transcription through stabilization of TATA box-bound TBP. The precursor of TFIIA is subjected to Taspase1-directed processing to generate α and β subunits. Although this processing has been assumed to be required for the promoter activation function of TFIIA, little is known about how the proces...

In this paper, a new two-level bipartitioning algorithm TLP, combining a hybrid clustering technique with an iterative improvement based partitioning process, is proposed. The hybrid clustering algorithm consisting of a local bottom-up clustering technique to merge modules and a global topdown ratiocut technique for decomposition can be used to reduce the partitioning complexity and improve the...

Transmission Line Pulse is a short pulse (25ns to 150ns) measurement of the current-voltage (I/V) characteristics of the ESD protection built into an integrated circuit. The short TLP pulses are used to simulate the short ESD pulse threats and integrated circuit must tolerate without being damaged. In this work the fundamental principles of how the TLP pulse is generated and used to create I-V ...

Introducción: la investigación actual y los artículos rastreados sobre adversidad temprana sesgos cognitivos en pacientes con trastorno límite de personalidad (TLP) evidencian relación entre estas variables gravedad síntomas clínicos este trastorno. Objetivo: revisar sistemáticamente evidencia temprana, agudización del TLP. El vacío investigativo tiene que ver el tipo específico su curso TLP di...

126 AI MAGAZINE The Defense Advanced Research Projects Agency (DARPA) Transfer Learning Program (TLP) explored the application of “transfer”—a notion well studied in psychology—to machine learning, where it was still novel. The aims of TLP were to understand and formally frame how this intuitively compelling psychological idea might apply in the computational context, build computational models...

Thg1-like protein (TLP) catalyzes the addition of a nucleotide to the 5'-end of truncated transfer RNA (tRNA) species in a Watson-Crick template-dependent manner. The reaction proceeds in two steps: the activation of the 5'-end by adenosine 5'-triphosphate (ATP)/guanosine 5'-triphosphate (GTP), followed by nucleotide addition. Structural analyses of the TLP and its reaction intermediates have r...

A preliminary analysis of immunoprecipitation followed by Western Blotting (WB) shows corin and TLP precipitate at the same level (approximately 50 KDa) and are recognized by the same antibodies. In parallel the tests of immunoprecipitation were improved by the use of cell extracts derived from lung cancer cells A549 and NCI-H23 with the aim of obtaining a precipitate containing only the TLP. I...