Abacavir (ABC) is administered either at 600 mg once daily (ABC 600 mg QD) or 300 mg twice daily (ABC 300 mg BID) in anti-human immunodeficiency virus (anti-HIV) combination therapy. Although ABC plasma pharmacokinetics following each regimen has been well defined, no study has directly compared the regimens with respect to pharmacokinetics of ABC's active intracellular anabolite, carbovir-trip...

Nested clade phylogeographical analysis (NCPA) and approximate Bayesian computation (ABC) have been used to test phylogeographical hypotheses. Multilocus NCPA tests null hypotheses, whereas ABC discriminates among a finite set of alternatives. The interpretive criteria of NCPA are explicit and allow complex models to be built from simple components. The interpretive criteria of ABC are ad hoc a...

The well-known ABC-conjecture is generally formulated as follows: The ABC-conjecture. Consider the set S of triples (A, B, C) ∈ N 3 such that ABC = 0, gcd{A, B, C} = 1 and A + B = C Then for every ǫ > 0, there exists a constant K ǫ such that C ≤ K ǫ · R(ABC) 1+ǫ for all triples (A, B, C) ∈ S, where R(ABC) denotes the square-free part of the product ABC. The ABC-conjecture is studied in many pap...

We develop the concept of ABC-Boost (Adaptive Base Class Boost) for multi-class classification and present ABC-MART, a concrete implementation of ABC-Boost. The original MART (Multiple Additive Regression Trees) algorithm has been very successful in large-scale applications. For binary classification, ABC-MART recovers MART. For multi-class classification, ABC-MART considerably improves MART, a...

An N-tiling of triangle ABC by triangle T (the “tile”) is a way of writing ABC as a union of N copies of T overlapping only at their boundaries. We continue the work of [1, 2] on classifying the possible triangle tilings. The results of all three papers together enable us to make some progress on two problems of Erdős about triangle tilings, one of which asks, “for which N is there an N-tiling ...

ABC (ATP-binding cassette) transporters are arguably the most important family of ATP-driven transporters in biology. Despite considerable effort and advances in determining the structures and physiology of these transporters, their fundamental molecular mechanisms remain elusive and highly controversial. How does ATP hydrolysis by ABC transporters drive their transport function? Part of the pr...

The artificial bee colony algorithm (ABC), a population based algorithm, provides solutions with better accuracy compared to other competitive population based algorithms. However, it suffers from slow convergence speed. We suggest modifications in search strategy of ABC to improve overall performance and named this modified algorithm, Efficient ABC algorithm (EABC). The performance of EABC is ...