To perform their job safely firefighters must be able to identify colours on industrial gas cylinders, portable fire extinguishers, road traffic signals and several pieces of firefighting equipment. Although good colour vision is necessary we believe that the existing colour vision standard, which bars entry to the fire service to applicants who fail more than two plates of the Ishihara test, i...

Natal body mass is a key predictor of viability and fitness in many animals. While variation therefore juvenile may be explained by genetic environmental factors, emerging evidence points to the gut microbiota as an important factor influencing host health. The known change during development, but it remains unclear whether microbiome predicts fitness, if does, at which developmental stage affe...

We consider a broad class of intertemporal economic problems and characterize the short-run long-run responses demand for good to permanent increase in its market price. Depending on interplay between self-productivity time discounting, we show that dynamic substitution effects can generate price elasticities opposite signs short run long run. (JEL D11, D15, H20, J22, J24)

BaCKgROUnD CLL11 is a large randomized phase III trial investigating first-line chemoimmunotherapy in CLL patients with comorbidities. The final stage 1 analysis recently showed that GA101 plus Clb (GClb) or rituximab plus Clb (RClb) has superior efficacy to chemotherapy with Clb alone. This abstract presents the final stage 2 analysis with efficacy and safety results of the head-to-head compar...

In November of 2007 a human adenovirus (HAdV) was isolated from a bronchoalveolar lavage (BAL) sample recovered from a biopsy of an AIDS patient who presented with fever, cough, tachycardia, and expiratory wheezes. To better understand the isolated virus, the genome was sequenced and analyzed using bioinformatic and phylogenomic analysis. The results suggest that this novel virus, which is prov...

Recent pharmacological discovery on trace amineassociated receptor, type 1(TAAR1) has emphasized importance of trace amines in pathogenesis of psychoses, such as schizophrenia. TAAR1 has many ligands, including tyramine, β-phenylethylamine (PEA), amphetamines, and 3’-iodothyronamine. Socalled D-neurons are putative producer of trace amines, endogenous ligands of TAAR1. The D-neuron is defined “...

BACKGROUND: In most organisms proper reductional chromosome segregation during meiosis I is strongly correlated with the presence of crossover recombination structures (chiasmata); recombination deficient mutants lack crossovers and suffer meiosis I nondisjunction. We report that these functions are separable in the fission yeast Schizosaccharomyces pombe. RESULTS: Intron mapping and expression...

Iron overload has been implicated in decreased bone mineral density. However, the effect of iron overload on osteoblast lineage cells remains poorly understood. The purpose of this study was to examine osteoblast differentiation, function, and apoptosis in iron-loaded cells from fetal rat calvaria. Cells were incubated with media supplemented with 0-10 microM ferrous sulfate (FeSO(4)) during di...

Endo beta-1,4-mannanases (beta-mannanases, EC 3.2.1.78), belonging to CAZy GH5 and GH26 families, catalyze the hydrolysis of structurally different mannans. In this study, the mannanase encoding gene of Aspergillus aculeatus VN was expressed in Aspergillus niger D15#26 using pAN 52-4 vector, under the control of PgpdA promoter and TtrpC terminator. In order to improve the hydrolytic capacity of...

BACKGROUND Symptoms of allergic rhinitis (AR) have a detrimental effect on quality of life. The AR-Patient Benefit Index (AR-PBI), a specific self-assessment tool has been developed to assess treatment-related benefit in two separate sections: the Patient Needs Questionnaire (PNQ) which explores the patient's expectations before treatment and the Patient Benefit Questionnaire (PBQ) which evalua...