نتایج جستجو برای: تست writhing
تعداد نتایج: 17487 فیلتر نتایج به سال:
Methanolic extract of Solanum trilobatum Linn. (MEST) belonging to the family of Solanacea was evaluated by hot plate and acetic acid induced writhing methods to assess its analgesic activity. The extract was also evaluated for its anti-inflammatory activity by subjecting into carrageenan, and cotton pellet induced granuloma tests for its effect on acute and chronic phase inflammation models in...
In this work, a series of arylpiperazine derivatives were synthesized and screened by in vivo pharmacological trials. Among the tested compounds, 2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)-1-phenylethanone (18) and 2-(4-(2,3-dimethylphenyl)piperazin-1-yl)-1-phenylethanone (19) exhibited potent analgesic activities in both the mice writhing and mice hot plate tests. They showed more than 70...
objective(s) the present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. materials and methods antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. results promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhi...
The uses of non-steroidal anti-inflammatory drugs (NSAIDs) are limited by a variety of side effects. So research on preparing new analgesic agents is important. According to some reports about the analgesic activity of hydrazide and hydrazine derivatives a new series of these compounds were synthesized in order to obtain new analgesic compounds. The final compounds 10a-10e and 15a-15d were pre...
Exploiting the “natural” frame of space curves, we formulate an intrinsic dynamics of a twisted elastic filament in a viscous fluid. Coupled nonlinear equations describing the temporal evolution of the filament’s complex curvature and twist density capture the dynamic interplay of twist and writhe. These equations are used to illustrate a remarkable nonlinear phenomenon: geometric untwisting of...
objective: premna integrifolia linn (family: verbenaceae) synonym of premna serratifolia has tremendous medicinal value. preliminary pharmacological studies were performed on the methanolic extract of premna integrifolia (mepi) bark to investigate neuropharmacological, analgesic, and anti-inflammatory activities. materials and methods: neuropharmacology study was done by open field and hole cro...
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