A marked tissue-specific increase in erythrocyte adenosine deaminase (ADA) activity is associated with an autosomal dominantly inherited hemolytic anemia. We investigated the molecular basis of ADA overproduction by studying reticulocyte ADA mRNA from affected individuals. Analysis of proband reticulocyte ADA cDNA clones revealed normal sequence. RNase mapping demonstrated that the amount of AD...

Adenosine deaminase (ADA) deficiency causes an autosomal recessive form of severe combined immunodeficiency and also less severe phenotypes, depending to a large degree on genotype. In general, ADA activity in cells of carriers is approximately half-normal. Unexpectedly, healthy first-degree relatives of two unrelated ADA-deficient severe combined immunodeficient patients (mother and brother in...

Intention der Fachgruppe: Software garantiert häufig direkt die Sicherheit für Menschen. Ada wird in internationalen Sicherheitsstandards empfohlen und unterstützt in einzigartiger Weise moderne Analyse, Design und Programmiermethoden und damit die Entwicklung großer zuverlässiger Software-Systeme. Die Fachgruppe will über die Konzepte von Ada und deren Bedeutung für die Softwaretechnologie inf...

The adaptive response is a cellular process to induce DNA repair enzymes in response to a challenge of alkylating agents. In this process Ada protein, the product of the ada gene, plays a major role; it accepts the methyl groups of the methylated DNA at the cysteine residues of its own molecule, and the methylated form of Ada protein promotes transcription of its own gene, thereby triggering in...

This paper describes an automated approach for generating Ada bindings from Java class files. We start with the set of Java features that require a visible Ada binding, and an Ada compiler’s definition of how to interface Ada and Java. We discuss how to obtain the Java definitions from the class file and then translate them into an Ada binding (using the GNAT binding approach). While it is poss...

INTRODUCTION Anti-TNF drugs have proven to be effective against spondyloarthritis (SpA), although 30% of patients fail to respond or experience adverse events leading to treatment discontinuation. In rheumatoid arthritis, the presence of anti-drug antibodies (ADA) against the first TNF inhibitor influences the outcome after switching. Our aim was to assess whether the response to a second anti-...