The enantioselective fluorination of readily available cyclic allylic chlorides with AgF has been accomplished using a Pd(0) catalyst and Trost bisphosphine ligand. The reactions proceed with unprecedented ease of operation for Pd-mediated nucleophilic fluorination, allowing access to highly enantioenriched cyclic allylic fluorides that bear diverse functional groups. Evidence that supports a m...

Highly enantioselective hydrogenation of various N-Boc-indoles proceeded successfully in the presence of the ruthenium complex generated from an appropriate ruthenium precursor and a trans-chelate chiral bisphosphine PhTRAP. Various 2- or 3-substituted indoles were converted into chiral indolines with high enantiomeric excesses (up to 95% ee). The PhTRAP-ruthenium catalyst was able to promote t...

objectives: multidrug resistance (mdr), which may be due to the over expression of p-glycoprotein (pgp) and/or mrp, is a major problem in neoadjuvant chemotherapy of osteosarcoma. the aim of this study was to investigate the role of tc-99m mibi scan for predicting the response to pre-operative chemotherapy. materials and methods: twenty-five patients (12 males and 13 females, aged between 8 and...

In the first part of this two-part article, the characteristics, potential uses, radiochemical purity and method of evaluating the activity of Tc99m will be discussed. In the second part of the article, the dosimetry of this radionuclide will be presented for various routes of administration as well as for various chem ical configurations, such as the pertechnetate ion, the colloid and the prot...