PURPOSE This study was undertaken to evaluate the significance of cyclooxygenase-2 (COX2) overexpression and the expression of somatostatin receptor (SSTR) subtypes in gastroenteropancreatic neuroendocrine tumors (GEP-NETs). MATERIALS AND METHODS Two hundred and forty-seven cases of GEP-NET, comprising 86 foregut and 156 hindgut primary NETs, and 5 metastatic NETs in the liver, were studied r...

The possible existence of an autocrine/paracrine role for SRIF in normal and neoplastic thyroid parafollicular C cells has supported the use of SRIF analogues in the treatment of patients with medullary thyroid carcinoma (MTC). In this study, we have investigated the expression of SRIF by immunohistochemistry and RT-PCR, and the expression of SRIF receptor (SSTR) subtypes by RT-PCR, in a series...

BACKGROUND Nearly half of stroke patients have impaired sensory discrimination, however, the neural structures that support post-stroke sensory function have not been described. OBJECTIVES 1) To evaluate the role of the primary somatosensory (S1) cortex in post-stroke sensory discrimination and 2) To determine the relationship between post-stroke sensory discrimination and structural integrit...

Notes nomenclaturales sur Solenanthus minimus Brand (Boraginaceae). Une espèce de Boraginaceae, Brand, décrite le territoire l'Iran est néotypifiée en raison l'indisponibilité du matériel original. Dans présent article, elle assignée au genre Rindera la base nouvellement collecté et description originale. Ainsi, Cynoglossum minimum (Brand) Greuter & Stier traité ici comme un synonyme R. bungei ...

This study investigated the impact of entrepreneurial determinants on ease doing business in five English. Speaking West African Countries (ESWACs) Nigeria, Ghana, Sierra Leone, Liberia and The Gambia. It used secondary data sourced from OECD World Bank. independent variables were Entrepreneurial Determinants (ED) regulatory framework peroxide by Small Medium Enterprise Sale Tax (SSTR); access ...

Introduction Peptide Receptor Radionuclide Therapy (PRRT) is a type of molecular-targeted endo-radionuclide therapy in which unsealed radiolabelled somatostatin analogues are specifically directed toward receptors (SSTR) over-expressed Neuroendocrine Neoplasms (NEN) and related malignancies. This modality has witnessed benchmark growth over last decade symbolizes remarkable development precisio...

A 30-year-old woman had a history of prolactinoma and primary hyperparathyroidism. She was diagnosed as having multiple endocrine neoplasia type 1 with gastrinoma and liver metastases. Octreotide therapy was started and the serum gastrin level decreased immediately. Octreotide continued to suppress gastrin secretion over the next 7 years. The Ki67/MIB1 proliferation index of this tumor was only...

OBJECTIVE GH-producing pituitary adenomas display two distinct morphological patterns of cytoplasmic GH-containing secretory granules, namely the densely and sparsely granulated somatotroph adenoma subtype. It is unknown whether these morphological variants reflect distinct pathophysiological entities at the molecular level. METHODS In 28 GH-producing adenoma tissues from a consecutive set of...

Recent studies all indicated that both the affinities and subdivision of Boraginaceae s.str. are unsatisfactorily resolved. Major open issues are the placement and affinities of Boraginaceae s.str. in Boraginales and the major clades of the family, with especially the large tribes Cynoglosseae and Eritrichieae repeatedly retrieved as non-monophyletic groups, and the doubtful monophyly of severa...