Performance-based earthquake engineering (PBEE) provides a robust alternative to traditional design. PBEE enables engineers estimate expected damage, repair costs, and economic losses due downtime for candidate design, potentially leading novel new designs or retrofit solutions. With the increasing application of light-frame structural systems, such as cold-formed steel (CFS) panels, in residen...

Amyloid Precursor Protein (APP) is regulated in a mitosis-specific manner and plays a role in proliferative signaling in cells. Though APP-derived Aβ generation has a well-established role in neurodegeneration, the mechanistic role of APP in this process is not fully understood. Here, we performed an unbiased, comprehensive analysis of the phosphoproteome signature in APP-null neuroblastoma cel...

BACKGROUND Ventilator-associated pneumonia (VAP) requires prompt and appropriate treatment. Since methicillin-resistant Staphylococcus aureus (MRSA) is a frequent pathogen in VAP, rapid identification of it, is pivotal. Our aim was to evaluate the utility of quantitative polymerase chain reaction (qPCR) as a useful method for etiologic diagnoses of MRSA pneumonia. METHODS We performed qPCR fo...

The present recommendations for dune removal or dune retreat on the Great Lakes for Federal Emergency Management Agency (FEMA) flood mapping purposes are based on a simple geometric method as outlined in FEMA (2009). The simple procedure establishes a relationship between dune survival and storm intensity. The method was adopted several decades ago when numerical models were inadequate for pred...

We have developed a framework for flood mitigation risk analysis that applies generally to floods, and have applied it in this study of flood mitigation risk analysis for the Raritan Basin in New Jersey, USA. The framework we have developed involves a conceptual model of the relation among meteorological activity, hydrological models, infrastructure intervention, fine-grained topography, and ec...

BACKGROUND Staphylococcus aureus is a common and significant pathogen in cystic fibrosis. We sought to determine if quantitative PCR (qPCR) and 16S rRNA gene sequencing could provide a rapid, culture-independent approach to the identification of S. aureus airway infections. METHODS We examined the sensitivity and specificity of two qPCR assays, targeting the femA and 16S rRNA gene, using cult...

BACKGROUND To estimate changes in the cost and utilization of Medicare among beneficiaries over age 65 who have been impacted by a natural disaster, we merged publically available county-level Medicare claims for the years 2008-2012 with Federal Emergency Management Agency (FEMA) data related to disasters in each U.S. County from 2007 to 2012. METHODS Fixed-effects generalized linear models w...

We have studied synaptic function in a transgenic mouse strain relevant to Alzheimer's disease (AD), overexpressing the 695 amino acid isoform of human amyloid precursor protein with K670N and M671L mutations (APP(695)SWE mice), which is associated with early-onset familial AD. Aged-transgenic mice had substantially elevated levels of Abeta (up to 22 micromol/gm) and displayed characteristic Ab...

Lung cancer remains the leading cause of cancer deaths in the United States and the rest of the world. The advent of molecularly directed therapies holds promise for improvement in therapeutic efficacy. Cytosolic phospholipase A2 (cPLA2) is associated with tumor progression and radioresistance in mouse tumor models. Utilizing the cPLA2 specific inhibitor PLA-695, we determined if cPLA2 inhibiti...