To analyze the characters of Down syndrome (DS) who failed to be diagnosed after prenatal screening and hope to be able to improve the programs of prenatal screening and reduce the missed diagnosis of DS. In this multicenter study, we collected the missed cases from 3 prenatal diagnosis centers and analyzed their characters. A total of 126 DS babies failed to be diagnosed after prenatal screeni...

OBJECTIVE This study examined the effect of a community pharmacy-based menopause education program on scores of the Management of Menopause (MoM) survey. The MoM survey is a tool administered to managed care organization members by the National Committee for Quality Assurance to determine the level of menopause-related education offered by their health care providers. The primary outcome was co...

Hybrid FEM/MoM methods combine the finite element method (FEM) and the method of moments (MoM) to model inhomogeneous unbounded problems. These two methods are coupled by enforcing field continuity on the boundary that separates the FEM and MoM regions. There are three ways of formulating hybrid FEM/MoM methods: outward-looking formulations, inward-looking formulations and combined formulations...

OBJECTIVES Third-body wear is believed to be one trigger for adverse results with metal-on-metal (MOM) bearings. Impingement and subluxation may release metal particles from MOM replacements. We therefore challenged MOM bearings with relevant debris types of cobalt-chrome alloy (CoCr), titanium alloy (Ti6Al4V) and polymethylmethacrylate bone cement (PMMA). METHODS Cement flakes (PMMA), CoCr a...

A straightforward statistical explanation is provided to show how differences between assay methods can affect the distribution of the multiples of the median (MoM). Evaluation of the impact of assay method differences reveals that the upper tails of the MoM distribution are not affected to the same degree as the lower tails of the distribution. The disparities in MoM distributions due to assay...

C. elegans embryonic cells have a common anterior/posterior (a/p) polarity that is apparent in the localization of the transcription factor POP-1. The level of nuclear POP-1 remains high in the anterior daughters of dividing cells but is lowered in the posterior daughters. To generate POP-1 asymmetry, most early embryonic cells require contact with signaling cells that express the ligand MOM-2/...

Metal-on-metal (MOM) hip resurfacing has recently been a popular prosthesis choice for the treatment of symptomatic arthritis, but results in the release of cobalt and chromium ions into the circulation that can be associated with adverse clinical effects. The mechanism underlying these effects remains unclear. While chromosomal aneuploidy and translocations are associated with this exposure, t...

OBJECTIVES A mixture model of crown-rump length (CRL)-dependent and CRL-independent nuchal translucency (NT) measurements has been proposed for antenatal screening for Down's syndrome. We here compare the efficacy of the mixture model method with the standard method, which uses NT multiple of the median (MoM) values in a single distribution. Settings A routine antenatal screening programme for ...