BACKGROUND DREAM (Downstream Regulatory Element Antagonistic Modulator) is a neuronal calcium sensor that was suggested to modulate TSH receptor activity and whose overexpression provokes an enlargement of the thyroid gland in transgenic mice. The aim of this study was to investigate somatic mutations and DREAM gene expression in human multinodular goiter (MNG). MATERIAL AND METHODS DNA and RNA...

Dream narration has a lengthy history in the Western literary tradition, functioning as the earliest iteration of the frame story. Dream narratives can be found in the Bible, and in Greek and Latin classical literature, but perhaps reached a zenith during the Medieval period, when dream visions became a central narratological strategy in theological texts and secular romances alike. Deriving fr...

I propose a narrative fabrication thesis of dream reports, according to which dream reports are often not accurate representations of experiences that occur during sleep. I begin with an overview of anti-experience theses of Norman Malcolm and Daniel Dennett who reject the received view of dreams, that dreams are experiences we have during sleep which are reported upon waking. Although rejectio...

INTRODUCTION The endogenous pain-relieving system depends in part on the regulation of nociceptive signals through binding of opioids to the corresponding opioid receptor. Interfering with the trans-repression effect of downstream regulatory element antagonist modulator (DREAM) on the transcription of the opioid dynorphin-encoding prodynorphin (pdyn) gene might enhance pain relief in the periph...

This article presents the affinity existing between the female dream narrative and the fairy tale genre. Although a large body of material has already been written about the connection between fairy tales and dreams, it has never been examined empirically using the tools and methods with which fairy tales have been studied. This article focuses on one dream narrative, documented in the framewor...

Downstream Regulatory Element Antagonist Modulator (DREAM) is a Ca2+-dependent transcriptional repressor expressed in the brain, thyroid gland and thymus. Here, we analyzed the function of DREAM and the related protein KChIP-2 in the immune system using transgenic (tg) mice expressing a cross-dominant active mutant (EFmDREAM) for DREAM and KChIPs Ca2+-dependent transcriptional derepression. EFm...

Protein kinase A-dependent derepression of the human prodynorphin gene is regulated by the differential occupancy of the Dyn downstream regulatory element (DRE) site. Here, we show that a direct protein-protein interaction between DREAM and the CREM repressor isoform, alphaCREM, prevents binding of DREAM to the DRE and suggests a mechanism for cyclic AMP-dependent derepression of the prodynorph...

One particular area of contention in discussions of Freudian dream theory and its relation to the neuroscientific evidence is the notion of “disguise-censorship” and its relation to dream bizarreness. The discussion to date, however, has neglected the conceptual basis of repression and disguise-censorship, and this paper aims to clarify the role of repression in dreaming and its contribution to...

In a collaborative study between academic centers in Boston and Leiden, the Netherlands (Wamsley et al. 2014), researchers studied dream delusions in 46 people with narcolepsy and cataplexy, comparing them with age-matched healthy controls (n = 41). The average age of the patients was 34.2 ± 10.9 years (SD), and 59 percent were female. A structured telephone interview was utilized to assess dre...

SUMMARY The occurrence of lucid dreaming (dreaming while being conscious that one is dreaming) has been verified for 5 selected subjects who signaled that they knew they were dreaming while continuing to dream during unequivocal REM sleep. The signals consisted of particular dream actions having observable concomitants and were performed in accordance with pre-sleep agreement. The ability of pr...